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PDB: 11 件

3TS8
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Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
分子名称: CDKN1A(p21) anti-sense strand, CDKN1A(p21) sense strand, Cellular tumor antigen p53, ...
著者Halazonetis, T.D, Emamzadah, S.
登録日2011-09-12
公開日2011-11-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element.
Mol Cancer Res, 9, 2011
1T4W
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Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1
分子名称: C.Elegans p53 tumor suppressor-like transcription factor, ZINC ION
著者Huyen, Y, Jeffrey, P.D, Derry, W.B, Rothman, J.H, Pavletich, N.P, Stavridi, E.S, Halazonetis, T.D.
登録日2004-04-30
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1.
Structure, 12, 2004
7P2G
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Identification of low micromolar SARS-CoV-2 Mpro inhibitors from hits identified by in silico screens
分子名称: (4~{R})-~{N}-(4-iodophenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase
著者Rempel, S, Halazonetis, T.D.
登録日2021-07-05
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Non-covalent SARS-CoV-2 M pro inhibitors developed from in silico screen hits.
Sci Rep, 12, 2022
1XNI
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Tandem Tudor Domain of 53BP1
分子名称: Tumor suppressor p53-binding protein 1
著者Huyen, Y, Zgheib, O, DiTullio Jr, R.A, Gorgoulis, V.G, Zacharatos, P, Petty, T.J, Sheston, E.A, Mellert, H.S, Stavridi, E.S, Halazonetis, T.D.
登録日2004-10-05
公開日2004-11-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Nature, 432, 2004
1LGQ
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Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein
分子名称: cell cycle checkpoint protein CHFR
著者Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D.
登録日2002-04-16
公開日2002-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure, 10, 2002
1LGP
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Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate
分子名称: TUNGSTATE(VI)ION, cell cycle checkpoint protein CHFR
著者Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D.
登録日2002-04-16
公開日2002-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure, 10, 2002
4MZR
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Crystal structure of a polypeptide p53 mutant bound to DNA
分子名称: Cellular tumor antigen p53, ZINC ION, consensus DNA anti-sense strand, ...
著者Emamzadah, S.T, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D.
登録日2013-09-30
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426, 2014
4MZI
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Crystal structure of a human mutant p53
分子名称: Cellular tumor antigen p53, ZINC ION
著者Emamzadah, S, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D.
登録日2013-09-30
公開日2014-01-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426, 2014
3Q01
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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
分子名称: Cellular tumor antigen p53, ZINC ION
著者Petty, T.J, Halazonetis, T.D.
登録日2010-12-15
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3Q05
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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
分子名称: Cellular tumor antigen p53, DNA (26-MER), ZINC ION
著者Petty, T.J, Halazonetis, T.D.
登録日2010-12-15
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011
3Q06
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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
分子名称: Cellular tumor antigen p53, DNA (26-MER), ZINC ION
著者Petty, T.J, Halazonetis, T.D.
登録日2010-12-15
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Embo J., 30, 2011

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件を2024-07-24に公開中

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