6G71
 
 | | Structure of CYP1232A24 from Arthrobacter sp. | | Descriptor: | 1,2-ETHANEDIOL, Cytochrome P450, FE (III) ION, ... | | Authors: | Dubiel, P, Sharma, M, Klenk, J, Hauer, B, Grogan, G. | | Deposit date: | 2018-04-04 | | Release date: | 2019-03-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Identification and characterization of cytochrome P450 1232A24 and 1232F1 from Arthrobacter sp. and their role in the metabolic pathway of papaverine.
J.Biochem., 166, 2019
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4A9W
 | | Flavin-containing monooxygenase from Stenotrophomonas maltophilia | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MONOOXYGENASE, SULFATE ION | | Authors: | Jensen, C.N, Cartwright, J, Hart, S, Turkenburg, J.P, Ali, S.T, Allen, M.J, Grogan, G. | | Deposit date: | 2011-11-29 | | Release date: | 2012-04-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | A Flavoprotein Monooxygenase that Catalyses a Baeyer-Villiger Reaction and Thioether Oxidation Using Nadh as the Nicotinamide Cofactor.
Chembiochem, 13, 2012
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3ZDN
 | | D11-C mutant of monoamine oxidase from Aspergillus niger | | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, MONOAMINE OXIDASE N | | Authors: | Frank, A, Ghislieri, D, Willies, S, Turner, N.J, Grogan, G. | | Deposit date: | 2012-11-29 | | Release date: | 2013-10-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products.
J.Am.Chem.Soc., 135, 2013
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4ALB
 | | Structure of Phenolic Acid Decarboxylase from Bacillus subtilis: Tyr19Ala mutant in complex with coumaric acid | | Descriptor: | 4'-HYDROXYCINNAMIC ACID, PHENOLIC ACID DECARBOXYLASE PADC | | Authors: | Frank, A, Eborall, W, Hyde, R, Hart, S, Turkenburg, J.P, Grogan, G. | | Deposit date: | 2012-03-02 | | Release date: | 2012-08-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.03 Å) | | Cite: | Mutational Analysis of Phenolic Acid Decarboxylase from Bacillus Subtilis (Bspad), which Converts Bio-Derived Phenolic Acids to Styrene Derivatives
Catal.Sci.Technol., 2, 2012
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5FJU
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5FJR
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5FJO
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5FJP
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6RYZ
 | | SalL with S-adenosyl methionine | | Descriptor: | 1,2-ETHANEDIOL, Adenosyl-chloride synthase, CHLORIDE ION, ... | | Authors: | McKean, I, Frese, A, Cuetos, A, Burley, G, Grogan, G. | | Deposit date: | 2019-06-12 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation.
Angew.Chem.Int.Ed.Engl., 58, 2019
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5FWN
 | | Imine Reductase from Amycolatopsis orientalis. Closed form in in complex with (R)- Methyltetrahydroisoquinoline | | Descriptor: | (1R)-1-methyl-1,2,3,4-tetrahydroisoquinoline, IMINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | | Deposit date: | 2016-02-18 | | Release date: | 2016-06-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Stereoselectivity and Structural Characterization of an Imine Reductase (Ired) from Amycolatopsis Orientalis
Acs Catalysis, 6, 2016
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6RZ2
 | | SalL with Chloroadenosine | | Descriptor: | 5'-CHLORO-5'-DEOXYADENOSINE, Adenosyl-chloride synthase | | Authors: | McKean, I, Frese, A, Cuetos, A, Burley, G, Grogan, G. | | Deposit date: | 2019-06-12 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation.
Angew.Chem.Int.Ed.Engl., 58, 2019
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5G6R
 | | Imine reductase from Aspergillus oryzae | | Descriptor: | IMINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | | Deposit date: | 2016-06-23 | | Release date: | 2017-05-31 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | A reductive aminase from Aspergillus oryzae.
Nat Chem, 9, 2017
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6G1H
 | | Amine Dehydrogenase from Petrotoga mobilis; open form | | Descriptor: | 1,2-ETHANEDIOL, Dihydrodipicolinate reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Beloti, L, Frese, A, Mayol, O, Vergne-Vaxelaire, C, Grogan, G. | | Deposit date: | 2018-03-21 | | Release date: | 2019-03-27 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | A family of native amine dehydrogenases for the asymmetric reductive amination of ketones
Nat Catal, 2019
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6SLE
 | | Structure of Reductive Aminase from Neosartorya fumigata in complex with NADP+ | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, putative | | Authors: | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | | Deposit date: | 2019-08-19 | | Release date: | 2020-06-24 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases.
Chem Sci, 11, 2020
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4C5O
 | | Flavin monooxygenase from Stenotrophomonas maltophilia. Q193R H194T mutant | | Descriptor: | FLAVIN MONOOXYGENASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | | Authors: | Jensen, C.N, Ali, S.T, Allen, M.J, Grogan, G. | | Deposit date: | 2013-09-13 | | Release date: | 2014-02-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Mutations of an Nad(P)H-Dependent Flavoprotein Monooxygenase that Influence Cofactor Promiscuity and Enantioselectivity.
FEBS Open Bio, 3, 2013
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5FR9
 | | Structure of transaminase ATA-117 arRmut11 from Arthrobacter sp. KNK168 inhibited with 1-(4-Bromophenyl)-2-fluoroethylamine | | Descriptor: | (R)-AMINE TRANSAMINASE, [4-[3-(4-bromophenyl)-3-oxidanylidene-propyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl phosphate | | Authors: | Cuetos, A, Kroutil, W, Lavandera, I, Grogan, G. | | Deposit date: | 2015-12-16 | | Release date: | 2016-03-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched Beta-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination.
Angew.Chem.Int.Ed.Engl., 55, 2016
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6TFN
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4ATQ
 | | GABA-transaminase A1R958 in complex with external aldimine PLP-GABA adduct | | Descriptor: | 4-AMINOBUTYRATE TRANSAMINASE, GAMMA-AMINO-BUTANOIC ACID, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Bruce, H, Tuan, A.N, Mangas Sanchez, J, Hart, S, Turkenburg, J.P, Grogan, G. | | Deposit date: | 2012-05-09 | | Release date: | 2012-10-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structures of a Gamma-Aminobutyrate (Gaba) Transaminase from the S-Triazine-Degrading Organism Arthrobacter Aurescens Tc1 in Complex with Plp and with its External Aldimine Plp- Gaba Adduct.
Acta Crystallogr.,Sect.F, 68, 2012
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4ATP
 | | Structure of GABA-transaminase A1R958 from Arthrobacter aurescens in complex with PLP | | Descriptor: | 4-AMINOBUTYRATE TRANSAMINASE, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Bruce, H, Tuan, A.N, Mangas Sanchez, J, Hart, S, Turkenburg, J.P, Grogan, G. | | Deposit date: | 2012-05-09 | | Release date: | 2012-10-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structures of a Gamma-Aminobutyrate (Gaba) Transaminase from the S-Triazine-Degrading Organism Arthrobacter Aurescens Tc1 in Complex with Plp and with its External Aldimine Plp- Gaba Adduct.
Acta Crystallogr.,Sect.F, 68, 2012
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4BMV
 | | Short-chain dehydrogenase from Sphingobium yanoikuyae in complex with NADPH | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SHORT-CHAIN DEHYDROGENASE | | Authors: | Man, H, Kedziora, K, Lavandera-Garcia, I, Gotor-Fernandez, V, Grogan, G. | | Deposit date: | 2013-05-10 | | Release date: | 2014-03-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of Alcohol Dehydrogenases from Ralstonia and Sphingobium Spp. Reveal the Molecular Basis for Their Recognition of 'Bulky-Bulky' Ketones
Top.Catal., 57, 2014
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5FYF
 | | Structure of CYP153A from Marinobacter aquaeolei | | Descriptor: | 1,2-ETHANEDIOL, CYTOCHROME P450, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Danesh Azari, H.R, Spandolf, C, Hoffman, S.M, Weissenborn, M, Hauer, B, Grogan, G. | | Deposit date: | 2016-03-07 | | Release date: | 2017-01-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structure-Guided Redesign of CYP153AM.aqfor the Improved Terminal Hydroxylation of Fatty Acids
Chemcatchem, 2016
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5FYG
 | | Structure of CYP153A from Marinobacter aquaeolei in complex with hydroxydodecanoic acid | | Descriptor: | 12-HYDROXYDODECANOIC ACID, CYTOCHROME P450, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Danesh-Azari, H.-R, Spandolf, C, Hoffman, S.M, Weissenborn, M, Hauer, B, Grogan, G. | | Deposit date: | 2016-03-07 | | Release date: | 2017-01-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Structure-Guided Redesign of CYP153AM.aqfor the Improved Terminal Hydroxylation of Fatty Acids
Chemcatchem, 2016
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5G4I
 | | PLP-dependent phospholyase A1RDF1 from Arthrobacter aurescens TC1 | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, PHOSPHATE ION, ... | | Authors: | Cuetos, A, Tuan, A.N, Mangas Sanchez, J, Grogan, G. | | Deposit date: | 2016-05-13 | | Release date: | 2016-10-19 | | Last modified: | 2017-03-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Basis for Phospholyase Activity of a Class III Transaminase Homologue.
Chembiochem, 17, 2016
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5G5A
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5G1V
 | | Linalool Dehydratase Isomerase: Selenomethionine Derivative | | Descriptor: | LINALOOL DEHYDRATASE ISOMERASE | | Authors: | Chambers, S, Hau, A, Man, H, Omar, M, Turkenburg, J.P, Grogan, G. | | Deposit date: | 2016-03-30 | | Release date: | 2017-01-11 | | Last modified: | 2017-02-22 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Structural and functional insights into asymmetric enzymatic dehydration of alkenols.
Nat. Chem. Biol., 13, 2017
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