8SG7
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4R8E
| Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Yersinia pestis | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | Authors: | Himiari, Z, Nanson, J.D, Swarbrick, C.M.D, Forwood, J.K. | Deposit date: | 2014-09-02 | Release date: | 2014-12-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis. Sci Rep, 5, 2015
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4RYB
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6WX7
| SOX2 bound to Importin-alpha 2 | Descriptor: | Importin subunit alpha-1, Transcription factor SOX-2 | Authors: | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | Deposit date: | 2020-05-09 | Release date: | 2020-10-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
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6WX9
| SOX2 bound to Importin-alpha 5 | Descriptor: | Importin subunit alpha-5, Transcription factor SOX-2 | Authors: | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | Deposit date: | 2020-05-10 | Release date: | 2020-10-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
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5KLT
| Prototypical P4[M]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[M]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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5KLR
| Prototypical P4[R]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[R]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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2Q2B
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4R4U
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6WPR
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5J36
| Crystal structure of 60-mer BFDV Capsid Protein | Descriptor: | Beak and feather disease virus capsid protein, PHOSPHATE ION | Authors: | Sarker, S, Raidal, S, Aragao, D, Forwood, J.K. | Deposit date: | 2016-03-30 | Release date: | 2016-05-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural insights into the assembly and regulation of distinct viral capsid complexes. Nat Commun, 7, 2016
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7JJM
| Crystal structure of Importin alpha 2 in complex with LSD1 NLS | Descriptor: | CHLORIDE ION, Importin subunit alpha-1, Lysine-specific histone demethylase 1A | Authors: | Tu, W.J, McGuaig, R, Tan, H.Y.A, Hardy, C, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. | Deposit date: | 2020-07-27 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020
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6PZN
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4R9Z
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8QXX
| HCMV DNA polymerase processivity factor UL44 phosphorylated NLS 410-433 bound to mouse importin alpha 2 | Descriptor: | DNA polymerase processivity factor, Importin subunit alpha-1 | Authors: | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-10-25 | Release date: | 2023-11-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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8QXW
| HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 | Descriptor: | DNA polymerase processivity factor, Importin subunit alpha-1 | Authors: | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-10-25 | Release date: | 2023-11-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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6PZM
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8SUD
| JC Polyomavirus LTA NLS bound to importin alpha 2 | Descriptor: | Importin subunit alpha-1, Large T antigen | Authors: | Cross, E.M, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-05-12 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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8Q8K
| KI Polyomavirus LTA NLS bound to importin alpha 2 | Descriptor: | Importin subunit alpha-1, Large T antigen | Authors: | Cross, E.M, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-08-18 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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6VFN
| Crystal structure of SpeG allosteric polyamine acetyltransferase from Bacillus thuringiensis in complex with spermine | Descriptor: | SPERMINE, Spermidine N1-acetyltransferase | Authors: | Tsimbalyuk, S, Shornikov, A, Le, V.T.B, Kuhn, M.L, Forwood, J.K. | Deposit date: | 2020-01-05 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | SpeG polyamine acetyltransferase enzyme from Bacillus thuringiensis forms a dodecameric structure and exhibits high catalytic efficiency. J.Struct.Biol., 210, 2020
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6BVV
| Nipah virus W protein C-terminus in complex with Importin alpha 3 | Descriptor: | Importin subunit alpha-3, Protein W | Authors: | Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-13 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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6BW1
| Hendra virus W protein C-terminus in complex with Importin alpha 1 | Descriptor: | Importin subunit alpha-1, Protein W | Authors: | Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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6BW0
| Nipah virus W protein C-terminus in complex with Importin alpha 1 | Descriptor: | Importin subunit alpha-1, Protein W | Authors: | Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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6BWB
| Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3 | Descriptor: | Importin subunit alpha-3, Protein W | Authors: | Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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5HHG
| Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex | Descriptor: | Importin subunit alpha-1, RNA-directed RNA polymerase NS5 | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-01-11 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
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