4JNJ
| Structure based engineering of streptavidin monomer with a reduced biotin dissociation rate | Descriptor: | BIOTIN, Streptavidin/Rhizavidin Hybrid, ZINC ION | Authors: | DeMonte, D, Drake, E.J, Hong Lim, K, Gulick, A.M, Park, S. | Deposit date: | 2013-03-15 | Release date: | 2013-05-29 | Last modified: | 2013-11-13 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Structure-based engineering of streptavidin monomer with a reduced biotin dissociation rate. Proteins, 81, 2013
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7TPS
| Crystal structure of ALPN-202 (engineered CD80 vIgD) in complex with PD-L1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Demonte, D.W, Maurer, M.F, Akutsu, M, Kimbung, Y.R, Logan, D.T, Walse, B. | Deposit date: | 2022-01-26 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity. Nat Commun, 13, 2022
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