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PDB: 64 results
1Y1A
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BU of 1y1a by Molmil
CRYSTAL STRUCTURE OF CALCIUM AND INTEGRIN BINDING PROTEIN
Descriptor: CALCIUM ION, Calcium and integrin binding 1 (calmyrin), GLUTATHIONE
Authors:Blamey, C.J, Ceccarelli, C, Naik, U.P, Bahnson, B.J.
Deposit date:2004-11-17
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of calcium- and integrin-binding protein 1: Insights into redox regulated functions
Protein Sci., 14, 2005
1Y6O
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BU of 1y6o by Molmil
Crystal structure of disulfide engineered porcine pancreatic phospholipase A2 to group-X isozyme in complex with inhibitor MJ33 and phosphate ions
Descriptor: 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PHOSPHATE ION, ...
Authors:Yu, B.Z, Pan, Y.H, Jassen, M.J.W, Bahnson, B.J, Jain, M.K.
Deposit date:2004-12-06
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and structural properties of disulfide engineered phospholipase a(2): insight into the role of disulfide bonding patterns.
Biochemistry, 44, 2005
4B05
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BU of 4b05 by Molmil
Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease
Descriptor: (1S)-1-[2-(difluoromethyl)pyridin-4-yl]-4-fluoro-1-(3-pyrimidin-5-ylphenyl)-1H-isoindol-3-amine, ACETATE ION, BETA-SECRETASE 1, ...
Authors:Jeppsson, F, Eketjall, S, Janson, J, Karlstrom, S, Gustavsson, S, Olsson, L.L, Radesater, A.C, Ploeger, B, Cebers, G, Kolmodin, K, Swahn, B.M, von Berg, S, Bueters, T, Falting, J.
Deposit date:2012-06-28
Release date:2012-10-17
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
J. Biol. Chem., 287, 2012
1RJW
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BU of 1rjw by Molmil
CRYSTAL STRUCTURE OF NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS STRAIN LLD-R
Descriptor: Alcohol dehydrogenase, TRIFLUOROETHANOL, ZINC ION
Authors:Ceccarelli, C, Bahnson, B.J.
Deposit date:2003-11-20
Release date:2004-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus: Insight into Thermostability and Cofactor Binding
Biochemistry, 43, 2004
3F9C
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BU of 3f9c by Molmil
Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by diisopropylfluorophosphate
Descriptor: DIISOPROPYL PHOSPHONATE, Platelet-activating factor acetylhydrolase
Authors:Samanta, U, Bahnson, B.J.
Deposit date:2008-11-13
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.
Biochem Pharmacol, 78, 2009
3G4E
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BU of 3g4e by Molmil
Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)
Descriptor: CALCIUM ION, Regucalcin
Authors:Chakraborti, S, Bahnson, B.J.
Deposit date:2009-02-03
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions .
Biochemistry, 49, 2010
3G4H
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BU of 3g4h by Molmil
Crystal structure of Human Senescence Marker Protein-30 (Zinc Bound)
Descriptor: Regucalcin, ZINC ION
Authors:Chakraborti, S, Bahnson, B.J.
Deposit date:2009-02-03
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions .
Biochemistry, 49, 2010
5T9I
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BU of 5t9i by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, Thermolysin, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-09
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
5T9Q
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BU of 5t9q by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, PHOSPHATE ION, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-09
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
5TAE
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BU of 5tae by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, PHOSPHATE ION, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-09
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
3PII
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BU of 3pii by Molmil
Crystal structure of Mutant of ht- Alcohol Dehydrogenase with substrate analogue butyramide
Descriptor: Alcohol dehydrogenase, BUTYRAMIDE, SULFATE ION, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2010-11-06
Release date:2011-11-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of mutant of ht- Alcohol dehydrogenase
To be Published
5TAD
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BU of 5tad by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, PHOSPHATE ION, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-09
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
3F96
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BU of 3f96 by Molmil
Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by sarin
Descriptor: Platelet-activating factor acetylhydrolase
Authors:Samanta, U, Bahnson, B.J.
Deposit date:2008-11-13
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.
Biochem Pharmacol, 78, 2009
5TAI
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BU of 5tai by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, Thermolysin, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-10
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
4B1C
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BU of 4b1c by Molmil
New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain
Descriptor: (2R)-2-cyclopropyl-5-methyl-2-[3-(5-prop-1-yn-1-ylpyridin-3-yl)phenyl]-2H-imidazol-4-amine, BETA-SECRETASE 1, DIMETHYL SULFOXIDE
Authors:Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y.
Deposit date:2012-07-10
Release date:2012-10-10
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.
J. Med. Chem., 55, 2012
5TAK
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BU of 5tak by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, Thermolysin, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-10
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
5TAJ
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BU of 5taj by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, Thermolysin, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-10
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.031 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
1FX9
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BU of 1fx9 by Molmil
CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + SULPHATE IONS)
Descriptor: 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PHOSPHOLIPASE A2, ...
Authors:Pan, Y.H, Epstein, T.M, Jain, M.K, Bahnson, B.J.
Deposit date:2000-09-25
Release date:2001-09-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry, 40, 2001
1FXF
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BU of 1fxf by Molmil
CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + PHOSPHATE IONS)
Descriptor: 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PHOSPHATE ION, ...
Authors:Pan, Y.H, Epstein, T.M, Jain, M.K, Bahnson, B.J.
Deposit date:2000-09-25
Release date:2001-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry, 40, 2001
5T9K
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BU of 5t9k by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, Thermolysin, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-09
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
4LDK
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BU of 4ldk by Molmil
FAD-linked sulfhydryl oxidase ALR mutation
Descriptor: FAD-linked sulfhydryl oxidase ALR, FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION
Authors:Dong, M, Ramadan, S, Thorpe, C, Bahnson, B.
Deposit date:2013-06-24
Release date:2014-07-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:FAD-linked sulfhydryl oxidase ALR mutation
To be Published
5TAC
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BU of 5tac by Molmil
Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
Descriptor: CALCIUM ION, LYSINE, Thermolysin, ...
Authors:Dong, M, Bahnson, B.J.
Deposit date:2016-09-09
Release date:2017-08-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Conformational Sampling Differences across the Arrhenius Plot Biphasic Break Point at Ambient Temperature in the Enzyme Thermolysin
To Be Published
4B1D
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BU of 4b1d by Molmil
New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain
Descriptor: (2S)-2-(4-methoxy-3,5-dimethylphenyl)-5-methyl-2-(3-pyrimidin-5-ylphenyl)-2H-imidazol-4-amine, ACETATE ION, BETA-SECRETASE 1
Authors:Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y.
Deposit date:2012-07-10
Release date:2012-10-10
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.
J. Med. Chem., 55, 2012
3DT9
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BU of 3dt9 by Molmil
Crystal Structure of Bovin Brain Platelet Activating Factor Acetylhydrolase Covalently Inhibited by Soman
Descriptor: (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, Brain Platelet-activating factor acetylhydrolase IB subunit alpha
Authors:Epstein, T.M, Samanta, U, Bahnson, B.J.
Deposit date:2008-07-14
Release date:2009-05-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin.
Biochemistry, 48, 2009
4B1E
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BU of 4b1e by Molmil
New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain
Descriptor: (2R)-2-methyl-5-phenyl-2-(3-pyridin-3-ylphenyl)-2,3-dihydro-1H-imidazol-4-amine, BETA-SECRETASE 1
Authors:Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y.
Deposit date:2012-07-10
Release date:2012-10-10
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.
J. Med. Chem., 55, 2012

225946

数据于2024-10-09公开中

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