3KPC
| Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, S-ADENOSYLMETHIONINE, Uncharacterized protein MJ0100 | 著者 | Lucas, M, Oyenarte, I, Garcia, I.G, Arribas, E.A, Encinar, J.A, Kortazar, D, Fernandez, J.A, Mato, J.M, Martinez-Chantar, M.L, Martinez-Cruz, L.A. | 登録日 | 2009-11-16 | 公開日 | 2010-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Binding of S-Methyl-5'-Thioadenosine and S-Adenosyl-l-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair. J.Mol.Biol., 396, 2010
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7QT1
| Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8S8 complex with substitution e170N | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit, ... | 著者 | Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2022-01-14 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378, 2022
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6DS0
| Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | 分子名称: | (1S)-1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, ... | 著者 | McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. | 登録日 | 2018-06-13 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.188 Å) | 主引用文献 | Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
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5ZWY
| Ribokinase from Leishmania donovani | 分子名称: | CHLORIDE ION, GLYCEROL, Ribokinase, ... | 著者 | Gatreddi, S, Vasudevan, D, Qureshi, I.A. | 登録日 | 2018-05-17 | 公開日 | 2019-05-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Unraveling structural insights of ribokinase from Leishmania donovani. Int.J.Biol.Macromol., 136, 2019
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2W2Q
| PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR | 分子名称: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | 著者 | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | 登録日 | 2008-11-03 | 公開日 | 2008-11-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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6DSL
| Consensus engineered intein (Cat) with atypical split site | 分子名称: | Consensus engineered intein CatC, Consensus engineered intein CatN | 著者 | Sekar, G, Stevens, A.J, Muir, T.W, Cowburn, D. | 登録日 | 2018-06-14 | 公開日 | 2018-09-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | An Atypical Mechanism of Split Intein Molecular Recognition and Folding. J. Am. Chem. Soc., 140, 2018
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5AWS
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8D9M
| Cryo-EM of the OmcZ nanowires from Geobacter sulfurreducens | 分子名称: | Cytochrome c, HEME C | 著者 | Wang, F, Chan, C.H, Mustafa, K, Hochbaum, A.I, Bond, D.R, Egelman, E.H. | 登録日 | 2022-06-10 | 公開日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times. Elife, 11, 2022
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5WJ4
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7QSW
| L8S8-complex forming RubisCO derived from ancestral sequence reconstruction of the last common ancestor of SSU-bearing Form I RubisCOs | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit, ... | 著者 | Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2022-01-14 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378, 2022
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4XCG
| Crystal structure of a hexadecameric TF55 complex from S. solfataricus, crystal form I | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Thermosome subunit alpha, Thermosome subunit beta | 著者 | Stewart, A.G, Smits, C, Chaston, J.J, Stock, D. | 登録日 | 2014-12-18 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.737 Å) | 主引用文献 | Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins. Structure, 24, 2016
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5AP6
| Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, DUAL SPECIFICITY PROTEIN KINASE TTK, ... | 著者 | Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.M, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R, Linardopoulos, S. | 登録日 | 2015-09-14 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
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4QJ7
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6U0A
| Human Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) with Glycerol | 分子名称: | Angiopoietin-related protein 4, GLYCEROL | 著者 | Tarver, C.L, Yuan, Q, Singhal, A.J, Ramaker, R, Cooper, S, Pusey, M.L. | 登録日 | 2019-08-14 | 公開日 | 2019-10-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Crystal Structures of Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) Reveal a Binding Pocket with Multiple Ligands To Be Published
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5IXG
| Crystal Structure of Burkholderia cenocepacia BcnB | 分子名称: | (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL TRIHYDROGEN DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, YceI | 著者 | Loutet, S.A, Murphy, M.E.P. | 登録日 | 2016-03-23 | 公開日 | 2017-03-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. MBio, 8, 2017
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5F95
| Crystal structure of GSK3b in complex with Compound 18: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide | 分子名称: | 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide, Glycogen synthase kinase-3 beta | 著者 | Lewis, H.A, Kish, K, Luo, G, Dubowchick, G.M. | 登録日 | 2015-12-09 | 公開日 | 2016-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.525 Å) | 主引用文献 | Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J.Med.Chem., 59, 2016
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7Q8A
| Crystal structure of tandem domain RRM1-2 of FUBP-interacting repressor (FIR) bound to FUSE ssDNA fragment | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(P*GP*T)-3'), Poly(U)-binding-splicing factor PUF60, ... | 著者 | Ni, X, Joerger, A.C, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-11-10 | 公開日 | 2022-11-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of tandem domain RRM1-2 of FIR bound to FUSE ssDNA fragment To Be Published
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5SER
| Crystal Structure of human phosphodiesterase 10 in complex with 4-N-(2-fluoroethyl)-4-N,2-dimethyl-3-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide | 分子名称: | MAGNESIUM ION, N~4~-(2-fluoroethyl)-N~4~,1-dimethyl-N~5~-[(4S)-2-phenyl[1,2,4]triazolo[1,5-a]pyridin-7-yl]-1H-pyrazole-4,5-dicarboxamide, ZINC ION, ... | 著者 | Joseph, C, Flohr, A, Benz, J, Schlatter, D, Rudolph, M.G. | 登録日 | 2022-01-21 | 公開日 | 2022-10-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios. J.Comput.Aided Mol.Des., 36, 2022
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5WN1
| APE1 exonuclease product complex | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), ... | 著者 | Freudenthal, B.D, Whitaker, A.M. | 登録日 | 2017-07-31 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
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3L1T
| E. coli NrfA sulfite ocmplex | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Cytochrome c-552, ... | 著者 | Clarke, T.A, Hemmings, A.M, Butt, J.N. | 登録日 | 2009-12-14 | 公開日 | 2010-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Kinetic and thermodynamic resolution of the interactions between sulfite and the pentahaem cytochrome NrfA from Escherichia coli Biochem.J., 431, 2010
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3L2Z
| Crystal structure of hydrated Biotin Protein Ligase from M. tuberculosis | 分子名称: | BirA bifunctional protein | 著者 | Gupta, V, Gupta, R.K, Khare, G, Salunke, D.M, Tyagi, A.K. | 登録日 | 2009-12-16 | 公開日 | 2010-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration. Plos One, 5, 2010
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5ARB
| Cooperative bio-metallic selectivity in a tailored protease enables creation of a C-C cross-coupling Heckase | 分子名称: | 5-methyl-2-(5-methylpyridin-2-yl)pyridine, CALCIUM ION, CHLORIDE ION, ... | 著者 | Sharma, M, Diaz-Rodriguez, A, Offen, W.A, Palm-Espling, M.E, Pordea, A, Wormald, M.R, Mcdonough, M, Davies, G.J, Davis, B.G. | 登録日 | 2015-09-24 | 公開日 | 2016-09-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase To be Published
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5SEH
| Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide | 分子名称: | 4-(azetidine-1-carbonyl)-1-methyl-N-[(4S)-2-(morpholin-4-yl)[1,2,4]triazolo[1,5-a]pyridin-7-yl]-1H-pyrazole-5-carboxamide, MAGNESIUM ION, ZINC ION, ... | 著者 | Joseph, C, Flohr, A, Benz, J, Schlatter, D, Rudolph, M.G. | 登録日 | 2022-01-21 | 公開日 | 2022-10-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios. J.Comput.Aided Mol.Des., 36, 2022
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5ARN
| Cu(I)-CSP3 (COPPER STORAGE PROTEIN 3) FROM METHYLOSINUS | 分子名称: | COPPER (I) ION, CSP3 | 著者 | Vita, N, Landolfi, G, Basle, A, Platsaki, S, Waldron, K, Dennison, C. | 登録日 | 2015-09-25 | 公開日 | 2016-10-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel Cytosolic Copper Storage Proteins To be Published
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4QOD
| The value crystal structure of apo quinone reductase 2 at 1.35A | 分子名称: | GLYCEROL, Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION | 著者 | Serriere, J, Boutin, J.A, Isabet, T, Antoine, M, Ferry, G. | 登録日 | 2014-06-20 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The value crystal structure of apo quinone reductase 2 at 1.35A To be Published
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