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Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-09-16
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

Crystal structure of main protease of SARS-CoV-2 complexed with inhibitor
Descriptor:	(1R,2S,5S)-3-[N-(difluoroacetyl)-3-methyl-L-valyl]-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopiperidin-3-yl]propan-2-yl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:	Chen, P, Khan, M.B, Lu, J, Arutyunova, E, Young, H.S, Lemieux, M.J.
Deposit date:	2023-01-11
Release date:	2023-12-06
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism. Acs Bio Med Chem Au, 3, 2023