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6AH3
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BU of 6ah3 by Molmil
Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate
分子名称: MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ...
著者Lan, P, Tan, M, Wu, J, Lei, M.
登録日2018-08-16
公開日2018-10-17
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.48 Å)
主引用文献Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
6AGB
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BU of 6agb by Molmil
Cryo-EM structure of yeast Ribonuclease P
分子名称: RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ...
著者Lan, P, Tan, M, Wu, J, Lei, M.
登録日2018-08-10
公開日2018-10-17
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.48 Å)
主引用文献Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
7C7A
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BU of 7c7a by Molmil
Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1
分子名称: Internal Transcribed Spacer 1, MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, ...
著者Lan, P, Wu, J, Lei, M.
登録日2020-05-24
公開日2020-07-08
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Science, 369, 2020
7C79
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BU of 7c79 by Molmil
Cryo-EM structure of yeast Ribonuclease MRP
分子名称: MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease MRP RNA subunit NME1, ...
著者Lan, P, Wu, J, Lei, M.
登録日2020-05-24
公開日2020-07-08
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Science, 369, 2020
2F9Q
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BU of 2f9q by Molmil
Crystal Structure of Human Cytochrome P450 2D6
分子名称: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Rowland, P.
登録日2005-12-06
公開日2005-12-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献Crystal Structure of Human Cytochrome P450 2D6
J.Biol.Chem., 281, 2006
8A4O
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BU of 8a4o by Molmil
Crystal structure of the Ustilago hordei effector protein Uvi2
分子名称: Effector protein Uvi2
著者Weiland, P, Bange, G, Altegoer, F.
登録日2022-06-13
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural and functional analysis of the cerato-platanin-like protein Cpl1 suggests diverging functions in smut fungi.
Mol Plant Pathol, 24, 2023
8A14
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BU of 8a14 by Molmil
Crystal structure of the cerato-platanin-like protein Cpl1 from Ustilago maydis
分子名称: Cerato-platatanin-like protein 1
著者Weiland, P, Bange, G, Altegoer, F.
登録日2022-05-31
公開日2023-05-17
最終更新日2023-06-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional analysis of the cerato-platanin-like protein Cpl1 suggests diverging functions in smut fungi.
Mol Plant Pathol, 24, 2023
1EP3
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BU of 1ep3 by Molmil
CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B. DATA COLLECTED UNDER CRYOGENIC CONDITIONS.
分子名称: DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FE2/S2 (INORGANIC) CLUSTER, ...
著者Rowland, P, Norager, S, Jensen, K.F, Larsen, S.
登録日2000-03-27
公開日2001-01-17
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des., 8, 2000
2DOR
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BU of 2dor by Molmil
DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS COMPLEXED WITH OROTATE
分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, OROTIC ACID
著者Rowland, P, Larsen, S.
登録日1998-05-11
公開日1998-08-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.
Protein Sci., 7, 1998
1DOR
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BU of 1dor by Molmil
DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS
分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE
著者Rowland, P, Larsen, S.
登録日1997-01-14
公開日1997-04-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.
Structure, 5, 1997
4GE3
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BU of 4ge3 by Molmil
Schizosaccharomyces pombe DJ-1 T114V mutant
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Uncharacterized protein C22E12.03c
著者Madzelan, P, Labunska, T, Wilson, M.A.
登録日2012-08-01
公開日2012-08-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Influence of peptide dipoles and hydrogen bonds on reactive cysteine pK(a) values in fission yeast DJ-1.
Febs J., 279, 2012
4GE0
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BU of 4ge0 by Molmil
Schizosaccharomyces pombe DJ-1 T114P mutant
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Uncharacterized protein C22E12.03c
著者Madzelan, P, Labunska, T, Wilson, M.A.
登録日2012-08-01
公開日2012-08-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Influence of peptide dipoles and hydrogen bonds on reactive cysteine pK(a) values in fission yeast DJ-1.
Febs J., 279, 2012
1EP2
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BU of 1ep2 by Molmil
CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B COMPLEXED WITH OROTATE
分子名称: DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FE2/S2 (INORGANIC) CLUSTER, ...
著者Rowland, P, Norager, S, Jensen, K.F, Larsen, S.
登録日2000-03-27
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des., 8, 2000
1EP1
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BU of 1ep1 by Molmil
CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B
分子名称: DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FE2/S2 (INORGANIC) CLUSTER, ...
著者Rowland, P, Norager, S, Jensen, K.F, Larsen, S.
登録日2000-03-27
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des., 8, 2000
8AJJ
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BU of 8ajj by Molmil
Crystal structure of the disulfide reductase MerA from Staphylococcus aureus
分子名称: Dihydrolipoamide dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, HISTIDINE
著者Weiland, P, Altegoer, F, Bange, G.
登録日2022-07-28
公開日2023-03-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus.
Mol.Microbiol., 119, 2023
8AJK
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BU of 8ajk by Molmil
Crystal structure of a C43S variant from the disulfide reductase MerA from Staphylococcus aureus
分子名称: FAD-containing oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Weiland, P, Altegoer, F, Bange, G.
登録日2022-07-28
公開日2023-03-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus.
Mol.Microbiol., 119, 2023
7Q7K
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BU of 7q7k by Molmil
JAK2 in complex with 4-(2-amino-8-methoxyquinazolin-6-yl)phenol
分子名称: 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol, Tyrosine-protein kinase JAK2
著者Rowland, P.
登録日2021-11-09
公開日2022-02-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J.Med.Chem., 65, 2022
7Q7I
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BU of 7q7i by Molmil
JAK2 in complex with 4-{8-methoxy-2-[(1-methyl-1H-pyrazol-4-yl)amino]quinazolin-6-yl}phenol
分子名称: 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol, Tyrosine-protein kinase JAK2
著者Rowland, P.
登録日2021-11-09
公開日2022-02-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J.Med.Chem., 65, 2022
7Q7L
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BU of 7q7l by Molmil
JAK2 in complex with 4-(2-amino-8-{[(2S)-1-hydroxypropan-2-yl]amino}quinazolin-6-yl)-5-ethyl-2-fluorophenol
分子名称: 4-[2-azanyl-8-[[(2~{S})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol, GLYCEROL, Tyrosine-protein kinase JAK2
著者Rowland, P.
登録日2021-11-09
公開日2022-02-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J.Med.Chem., 65, 2022
7Q7W
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BU of 7q7w by Molmil
JAK2 in complex with 4-(2-{[5-(dimethylamino)pentyl]amino}-8-{[(2S)-1-hydroxypropan-2-yl]amino}quinazolin-6-yl)-5-ethyl-2-fluorophenol
分子名称: 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{S})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol, Tyrosine-protein kinase JAK2
著者Rowland, P.
登録日2021-11-09
公開日2022-02-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J.Med.Chem., 65, 2022
8OLU
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BU of 8olu by Molmil
Leishmania tarentolae proteasome 20S subunit in complex with 1-Benzyl-N-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
分子名称: Proteasome alpha 1 subunit, putative, Proteasome alpha 5 subunit, ...
著者Rowland, P.
登録日2023-03-30
公開日2023-08-09
最終更新日2023-08-23
実験手法ELECTRON MICROSCOPY (2.59 Å)
主引用文献Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
J.Med.Chem., 66, 2023
6QM8
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BU of 6qm8 by Molmil
Leishmania tarentolae proteasome 20S subunit apo structure
分子名称: Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ...
著者Rowland, P, Goswami, P.
登録日2019-02-01
公開日2019-04-17
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116, 2019
7POS
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BU of 7pos by Molmil
PI3 kinase delta in complex with 5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-N-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1-yl}pyridin-3-yl)pyridine-3-sulfonamide
分子名称: 5-(3,6-dihydro-2~{H}-pyran-4-yl)-2-methoxy-~{N}-[5-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]pyridin-3-yl]pyridine-3-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Rowland, P, Convery, M.
登録日2021-09-09
公開日2021-09-29
最終更新日2021-10-06
実験手法X-RAY DIFFRACTION (2.493 Å)
主引用文献Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode.
J.Med.Chem., 64, 2021
7POT
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BU of 7pot by Molmil
PI3 kinase delta in complex with N-[5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxypyridin-3-yl]benzenesulfonamide
分子名称: N-[5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-pyridin-3-yl]benzenesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Rowland, P, Convery, M.
登録日2021-09-09
公開日2021-09-29
最終更新日2021-10-06
実験手法X-RAY DIFFRACTION (2.391 Å)
主引用文献Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode.
J.Med.Chem., 64, 2021
7POP
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BU of 7pop by Molmil
PI3 kinase delta in complex with 5-[3,6-dihydro-2H-pyran-4-yl]-2-methoxy-N-[2-methylpyridin-4-yl]pyridine-3-sulfonamide
分子名称: 5-[3,6-dihydro-2H-pyran-4-yl]-2-methoxy-N-[2-methylpyridin-4-yl]pyridine-3-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Rowland, P, Convery, M.
登録日2021-09-09
公開日2021-09-29
最終更新日2021-10-06
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode.
J.Med.Chem., 64, 2021

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