8I16
| Crystal structure of the selenomethionine (SeMet)-derived Cas12g (D513A) mutant | 分子名称: | Cas12g, ZINC ION | 著者 | Zhang, B, Chen, J, Ye, Y.M, OuYang, S.Y. | 登録日 | 2023-01-12 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structural transitions upon guide RNA binding and their importance in Cas12g-mediated RNA cleavage. Plos Genet., 19, 2023
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8IN4
| Eisenia hydrolysis-enhancing protein from Aplysia kurodai | 分子名称: | 25 kDa polyphenol-binding protein, ACETYL GROUP, GLYCEROL | 著者 | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | 登録日 | 2023-03-08 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IN6
| Eisenia hydrolysis-enhancing protein from Aplysia kurodai complex with tannic acid | 分子名称: | 25 kDa polyphenol-binding protein, BETA-1,2,3,4,6-PENTA-O-GALLOYL-D-GLUCOPYRANOSE | 著者 | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | 登録日 | 2023-03-08 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IN1
| beta-glucosidase protein from Aplysia kurodai | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-Glucosidase, alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | 登録日 | 2023-03-08 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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8IN3
| Eisenia hydrolysis-enhancing protein from Aplysia kurodai | 分子名称: | 25 kDa polyphenol-binding protein, GLYCEROL | 著者 | Sun, X.M, Ye, Y.X, Kato, K, Yu, J, Yao, M. | 登録日 | 2023-03-08 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife, 12, 2023
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7D2L
| Crystal structure of the Cas12i1 R-loop complex before target DNA cleavage | 分子名称: | 12i1-D647A, CITRIC ACID, DNA (26-MER), ... | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | 登録日 | 2020-09-16 | 公開日 | 2021-05-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
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7D8C
| Crystal structure of the Cas12i1-crRNA binary complex | 分子名称: | 12i1, CITRIC ACID, RNA (3-MER), ... | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | 登録日 | 2020-10-07 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
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7D3J
| Crystal structure of the Cas12i1 R-loop complex after target DNA cleavage | 分子名称: | 12i1-WT, CITRIC ACID, DNA (23-MER), ... | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | 登録日 | 2020-09-19 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
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7EU9
| Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage | 分子名称: | CITRIC ACID, Cas12i1 D647A mutant, DNA (24-MER), ... | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | 登録日 | 2021-05-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-23 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
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8IJK
| human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 | 分子名称: | Calmodulin-1, N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Ma, D, Guo, J. | 登録日 | 2023-02-27 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol., 2024
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7KID
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | 分子名称: | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KIC
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KIB
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Palte, R.L, Hayes, R.P. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7VS2
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7X3X
| Cryo-EM structure of N1 nucleosome-RA | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3W
| Cryo-EM structure of ISW1-N1 nucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3V
| Cryo-EM structure of IOC3-N2 nucleosome | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3T
| Cryo-EM structure of ISW1a-dinucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (343-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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2LKP
| solution structure of apo-NmtR | 分子名称: | HTH-type transcriptional regulator NmtR | 著者 | Lee, C, Giedroc, D. | 登録日 | 2011-10-18 | 公開日 | 2012-04-18 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Mycobacterium tuberculosis NmtR in the Apo State: Insights into Ni(II)-Mediated Allostery. Biochemistry, 51, 2012
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6NKH
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6NKK
| Structure of PhqE Reductase/Diels-Alderase from Penicillium fellutanum in complex with NADP+ and premalbrancheamide | 分子名称: | (5aS,12aS,13aS)-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase | 著者 | Newmister, S.A, Dan, Q, Smith, J.L, Sherman, D.H. | 登録日 | 2019-01-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nat.Chem., 11, 2019
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6NKI
| Structure of PhqB Reductase Domain from Penicillium fellutanum | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NRPS | 著者 | Dan, Q, Newmister, S.A, Smith, J.L, Sherman, D.H. | 登録日 | 2019-01-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nat.Chem., 11, 2019
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6NKM
| Structure of PhqE D166N Reductase/Diels-Alderase from Penicillium fellutanum in complex with NADP+ and substrate | 分子名称: | 3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-8H-pyrrolo[1,2-a]pyrazin-5-ium-1-olate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase | 著者 | Newmister, S.A, Dan, Q, Smith, J.L, Sherman, D.H. | 登録日 | 2019-01-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.896 Å) | 主引用文献 | Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nat.Chem., 11, 2019
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7E44
| Crystal structure of NudC complexed with dpCoA | 分子名称: | DEPHOSPHO COENZYME A, NADH pyrophosphatase, ZINC ION | 著者 | Zhou, W, Guan, Z.Y, Yin, P, Zhang, D.L. | 登録日 | 2021-02-10 | 公開日 | 2021-07-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into dpCoA-RNA decapping by NudC. Rna Biol., 18, 2021
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7E0X
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