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Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives
分子名称:	2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile, Androgen receptor, GLYCEROL
著者	Wilson, K.P.
登録日	2016-09-07
公開日	2017-04-26
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives. Bioorg. Med. Chem. Lett., 27, 2017

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives
分子名称:	2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-methylbenzonitrile, Androgen receptor, GLYCEROL
著者	Wilson, K.P.
登録日	2016-09-07
公開日	2017-04-26
実験手法	X-RAY DIFFRACTION (2.71 Å)
主引用文献	Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives. Bioorg. Med. Chem. Lett., 27, 2017

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III
分子名称:	4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, GLYCEROL
著者	Wilson, K.P.
登録日	2017-03-22
公開日	2017-05-24
最終更新日	2017-11-22
実験手法	X-RAY DIFFRACTION (1.44 Å)
主引用文献	Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg. Med. Chem., 25, 2017

Stapled-peptides tailored against initiation of translation
分子名称:	1,2-ETHANEDIOL, ACE-LYS-LYS-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-PHE-ARG-ARG, Eukaryotic translation initiation factor 4E, ...
著者	Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Yano, J.
登録日	2018-04-04
公開日	2019-02-20
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019