Search by PDB author

4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors
分子名称:	2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4-yl)pteridin-7(8H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L.
登録日	2010-08-05
公開日	2010-09-22
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 20, 2010

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
分子名称:	2-amino-8-(trans-4-methoxycyclohexyl)-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L.
登録日	2010-11-29
公開日	2011-02-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.91 Å)
主引用文献	Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 21, 2011

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
分子名称:	4-amino-2-methyl-N-(1H-pyrazol-3-yl)quinazoline-8-carboxamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L.
登録日	2010-11-30
公開日	2011-02-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 21, 2011