6SAK
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7OWC
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7OWD
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3F89
| NEMO CoZi domain | 分子名称: | NF-kappa-B essential modulator | 著者 | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | 登録日 | 2008-11-11 | 公開日 | 2009-03-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation Cell(Cambridge,Mass.), 136, 2009
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8UYF
| Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer | 分子名称: | Serine/threonine-protein kinase Pink1, mitochondrial | 著者 | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | 登録日 | 2023-11-13 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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8UYH
| Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ... | 著者 | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | 登録日 | 2023-11-13 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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8UYI
| Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ... | 著者 | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | 登録日 | 2023-11-13 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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6W9O
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6W9R
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6EQI
| Structure of PINK1 bound to ubiquitin | 分子名称: | GLYCEROL, Nb696, Serine/threonine-protein kinase PINK1, ... | 著者 | Schubert, A.F, Gladkova, C, Pardon, E, Wagstaff, J.L, Freund, S.M.V, Steyaert, J, Maslen, S, Komander, D. | 登録日 | 2017-10-13 | 公開日 | 2017-11-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of PINK1 in complex with its substrate ubiquitin. Nature, 552, 2017
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6FFA
| FMDV Leader protease bound to substrate ISG15 | 分子名称: | GLYCEROL, Lbpro, SULFATE ION, ... | 著者 | Swatek, K.N, Pruneda, J.N, Komander, D. | 登録日 | 2018-01-05 | 公開日 | 2018-02-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6W9S
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6XA9
| SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide | 分子名称: | GLYCEROL, ISG15 CTD-propargylamide, Non-structural protein 3, ... | 著者 | Klemm, T, Calleja, D.J, Richardson, L.W, Lechtenberg, B.C, Komander, D. | 登録日 | 2020-06-04 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. Embo J., 39, 2020
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6XAA
| SARS CoV-2 PLpro in complex with ubiquitin propargylamide | 分子名称: | Non-structural protein 3, Ubiquitin-propargylamide, ZINC ION | 著者 | Klemm, T, Calleja, D.J, Richardson, L.W, Lechtenberg, B.C, Komander, D. | 登録日 | 2020-06-04 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. Embo J., 39, 2020
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4OYJ
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4OYK
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7T3X
| Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant | 分子名称: | Serine/threonine-protein kinase PINK1 | 著者 | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | 登録日 | 2021-12-09 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | 主引用文献 | Activation mechanism of PINK1. Nature, 602, 2022
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7T4N
| Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | 分子名称: | Serine/threonine-protein kinase PINK1, putative | 著者 | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | 登録日 | 2021-12-10 | 公開日 | 2022-01-12 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | 主引用文献 | Activation mechanism of PINK1. Nature, 602, 2022
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7T4K
| Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C helix in chain B | 分子名称: | Serine/threonine-protein kinase PINK1, putative | 著者 | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | 登録日 | 2021-12-10 | 公開日 | 2022-01-12 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Activation mechanism of PINK1. Nature, 602, 2022
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7T4M
| Structure of dodecameric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | 分子名称: | Serine/threonine-protein kinase PINK1, putative | 著者 | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | 登録日 | 2021-12-10 | 公開日 | 2022-01-12 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Activation mechanism of PINK1. Nature, 602, 2022
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7T4L
| Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with extended alpha-C helix in chain B | 分子名称: | Serine/threonine-protein kinase PINK1, putative | 著者 | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | 登録日 | 2021-12-10 | 公開日 | 2022-01-12 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Activation mechanism of PINK1. Nature, 602, 2022
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7TZJ
| SARS CoV-2 PLpro in complex with inhibitor 3k | 分子名称: | DIMETHYL SULFOXIDE, N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Papain-like protease, ... | 著者 | Calleja, D.J, Klemm, T, Lechtenberg, B.C, Kuchel, N.W, Lessene, G, Komander, D. | 登録日 | 2022-02-15 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. Front Chem, 10, 2022
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5HAM
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1H1W
| High resolution crystal structure of the human PDK1 catalytic domain | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | 著者 | Biondi, R.M, Komander, D, Thomas, C.C, Lizcano, J.M, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2002-07-23 | 公開日 | 2003-07-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | High Resolution Crystal Structure of the Human Pdk1 Catalytic Domain Defines the Regulatory Phosphopeptide Docking Site Embo J., 21, 2003
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5HAF
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