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Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and factor X substrate peptide fragment(39mer-4Ser)
分子名称:	ACETATE ION, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ...
著者	McDonough, M.A, Pfeffer, I.
登録日	2016-05-05
公開日	2017-05-24
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019

5JZA

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese and N-oxalylglycine
分子名称:	Aspartyl/asparaginyl beta-hydroxylase, GLYCEROL, MANGANESE (II) ION, ...
著者	McDonough, M.A, Pfeffer, I.
登録日	2016-05-16
公開日	2017-05-24
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.14 Å)
主引用文献	Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019

5JZU

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and factor X substrate peptide fragment (26mer)
分子名称:	Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, MANGANESE (II) ION, ...
著者	McDonough, M.A, Pfeffer, I.
登録日	2016-05-17
公開日	2017-06-07
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019

5JZ8

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine, and factor X substrate peptide fragment (39mer)
分子名称:	ACETATE ION, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ...
著者	McDonough, M.A, Pfeffer, I.
登録日	2016-05-16
公開日	2017-05-24
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.095 Å)
主引用文献	Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019

2WPX

Tandem GNAT protein from the clavulanic acid biosynthesis pathway (with AcCoA)
分子名称:	ACETYL COENZYME *A, GLYCEROL, ORF14
著者	Iqbal, A, Arunlanantham, H, McDonough, M.A, Chowdhury, R, Clifton, I.J.
登録日	2009-08-11
公開日	2009-12-29
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.31 Å)
主引用文献	Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins, 78, 2010

5JZ6

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese and L-malate
分子名称:	(2S)-2-hydroxybutanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, GLYCEROL, ...
著者	McDonough, M.A, Pfeffer, I.
登録日	2016-05-16
公開日	2017-05-24
最終更新日	2019-11-06
実験手法	X-RAY DIFFRACTION (2.354 Å)
主引用文献	Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019

2Y34

S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN9
分子名称:	EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
著者	Chowdhury, R, McDonough, M.A, Schofield, C.J.
登録日	2010-12-18
公開日	2010-12-29
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.01 Å)
主引用文献	Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). J. Mol. Biol., 410, 2011

2Y33

S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN9
分子名称:	EGL NINE HOMOLOG 1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ZINC ION
著者	Chowdhury, R, Clifton, I.J, Schofield, C.J.
登録日	2010-12-18
公開日	2010-12-29
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1) J.Mol.Biol., 410, 2011

2ZGD

Asn-hydroxylation stabilises the ankyrin repeat domain fold
分子名称:	3 repeat synthetic ankyrin, CADMIUM ION, CHLORIDE ION
著者	McDonough, M.A, Schofield, C.J.
登録日	2008-01-21
公開日	2008-02-05
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Mol Biosyst, 5, 2009

2ZGG

Asn-hydroxylation stabilises the ankyrin repeat domain fold
分子名称:	3 repeat synthetic ankyrin, CADMIUM ION, COBALT (II) ION
著者	McDonough, M.A, Schofield, C.J.
登録日	2008-01-21
公開日	2008-02-05
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Mol Biosyst, 5, 2009

2XUM

FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER)
分子名称:	ASP-SUBSTRATE PEPTIDE 2, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, N-OXALYLGLYCINE, ...
著者	Chowdhury, R, McDonough, M.A, Schofield, C.J.
登録日	2010-10-19
公開日	2010-12-22
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J. Biol. Chem., 286, 2011

5L9V

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-1)
分子名称:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-11
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.829 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAS

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
分子名称:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-14
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.749 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBC

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称:	BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.816 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBB

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
分子名称:	2-OXOGLUTARIC ACID, Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-10
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LA9

HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)
分子名称:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-14
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.813 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9R

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)
分子名称:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-10
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.81 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBF

HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-16
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.8995 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAT

HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称:	BICARBONATE ION, Egl nine homolog 1, GLYCEROL, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

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