7NXK
| Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175 | Descriptor: | (E)-N-[4-[(1R,3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide, Cyclin-K, Cyclin-dependent kinase 12 | Authors: | Anand, K, Dust, S, Kaltheuner, I.H, Geyer, M. | Deposit date: | 2021-03-18 | Release date: | 2021-05-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur.J.Med.Chem., 221, 2021
|
|
2M2F
| The membran-proximal domain of ADAM17 | Descriptor: | Disintegrin and metalloproteinase domain-containing protein 17 | Authors: | Duesterhoeft, S, Jung, S, Hung, C, Tholey, A, Soennichsen, F.D, Groetzinger, J, Lorenzen, I. | Deposit date: | 2012-12-20 | Release date: | 2013-04-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase. J.Am.Chem.Soc., 135, 2013
|
|
7NXJ
| Crystal structure of human Cdk13/Cyclin K in complex with the inhibitor THZ531 | Descriptor: | Cyclin-K, Cyclin-dependent kinase 13, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide | Authors: | Anand, K, Greifenberg, A.K, Kaltheuner, I.H, Geyer, M. | Deposit date: | 2021-03-18 | Release date: | 2021-05-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur.J.Med.Chem., 221, 2021
|
|
2LVL
| NMR Structure the lantibiotic immunity protein SpaI | Descriptor: | SpaI | Authors: | Christ, N, Bochmann, S, Gottstein, D, Duchardt-Ferner, E, Hellmich, U.A, Duesterhus, S, Koetter, P, Guentert, P, Entian, K, Woehnert, J. | Deposit date: | 2012-07-06 | Release date: | 2012-08-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The First Structure of a Lantibiotic Immunity Protein, SpaI from Bacillus subtilis, Reveals a Novel Fold. J.Biol.Chem., 287, 2012
|
|
2N32
| NMR solution structure of the N-terminal domain of NisI, a lipoprotein from Lactococcus lactis which confers immunity against nisin | Descriptor: | Nisin immunity protein | Authors: | Hacker, C, Christ, N.A, Korn, S, Duchardt-Ferner, E, Hellmich, U.A, Duesterhus, S, Koetter, P, Entian, K, Woehnert, J. | Deposit date: | 2015-05-21 | Release date: | 2015-10-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin. J.Biol.Chem., 290, 2015
|
|
2N2E
| NMR solution structure of the C-terminal domain of NisI, a lipoprotein from Lactococcus lactis which confers immunity against nisin | Descriptor: | Nisin immunity protein | Authors: | Hacker, C, Christ, N.A, Korn, S, Duchardt-Ferner, E, Hellmich, U.A, Duesterhus, S, Koetter, P, Entian, K, Woehnert, J. | Deposit date: | 2015-05-08 | Release date: | 2015-10-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin. J.Biol.Chem., 290, 2015
|
|