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P38 Alpha kinase complexed with a 5-amino-pyrazole based inhibitor
Descriptor:	5-amino-N-[5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl]-1-phenyl-1H-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14
Authors:	Sack, J.S.
Deposit date:	2010-08-10
Release date:	2010-11-17
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.21 Å)
Cite:	5-Amino-pyrazoles as potent and selective p38α inhibitors Bioorg.Med.Chem.Lett., 20, 2010

P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor
Descriptor:	3-[(6-benzoyl-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]-N-cyclopropyl-4-methylbenzamide, Mitogen-activated protein kinase 14
Authors:	Sack, J.S.
Deposit date:	2011-05-20
Release date:	2012-02-01
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 21, 2011