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EGFR kinase domain mutant "TMLR" with pyridone compound 2: 4-[2-(4-chlorophenyl)ethylamino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide
Descriptor:	4-[2-(4-chlorophenyl)ethylamino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide, Epidermal growth factor receptor
Authors:	Eigenbrot, C, Yu, C.
Deposit date:	2015-11-05
Release date:	2015-12-30
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR. Acs Med.Chem.Lett., 7, 2016

EGFR kinase domain with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide
Descriptor:	4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide, Epidermal growth factor receptor
Authors:	Eigenbrot, C, Yu, C.
Deposit date:	2015-11-05
Release date:	2015-12-30
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR. Acs Med.Chem.Lett., 7, 2016