4LWH
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![BU of 4lwh by Molmil](/molmil-images/mine/4lwh) | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 | Descriptor: | Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazol-5-yl}cyclopropanecarboxamide | Authors: | Li, J, Shi, F, Xiong, B, He, J. | Deposit date: | 2013-07-27 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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6Z2M
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![BU of 6z2m by Molmil](/molmil-images/mine/6z2m) | H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 antibody, Spike glycoprotein, ... | Authors: | Naismith, J.H, Ren, J, Zhou, D, Zhao, Y, Stuart, D.I. | Deposit date: | 2020-05-17 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural characterisation of a nanobody derived from a naive library that neutralises SARS-CoV-2 To Be Published
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6YZ7
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![BU of 6yz7 by Molmil](/molmil-images/mine/6yz7) | H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Cr3022, Antibody light chain, ... | Authors: | Naismith, J.H, Ren, J, Zhou, D, Zhao, Y, Stuart, D.I. | Deposit date: | 2020-05-06 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural characterisation of a nanobody derived from a naive library that neutralises SARS-CoV-2 To Be Published, 2020
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6J73
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![BU of 6j73 by Molmil](/molmil-images/mine/6j73) | Crystal structure of IniA from Mycobacterium smegmatis | Descriptor: | Isoniazid inducible gene protein IniA | Authors: | Wang, M.F, Guo, X.Y, Hu, J.J, Li, J, Rao, Z.H. | Deposit date: | 2019-01-16 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.211 Å) | Cite: | Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun, 10, 2019
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4LWI
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![BU of 4lwi by Molmil](/molmil-images/mine/4lwi) | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6 | Descriptor: | Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide | Authors: | Li, J, Shi, F, Xiong, B, He, J. | Deposit date: | 2013-07-27 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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4LWE
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![BU of 4lwe by Molmil](/molmil-images/mine/4lwe) | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2 | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide | Authors: | Li, J, Shi, F, Xiong, B, He, J. | Deposit date: | 2013-07-27 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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4LWG
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![BU of 4lwg by Molmil](/molmil-images/mine/4lwg) | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4 | Descriptor: | 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone, Heat shock protein HSP 90-alpha | Authors: | Li, J, Shi, F, Xiong, B, He, J. | Deposit date: | 2013-07-27 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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6CN8
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![BU of 6cn8 by Molmil](/molmil-images/mine/6cn8) | High-resolution structure of ClpC1-NTD binding to Rufomycin-I | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpC1, CHLORIDE ION, PHOSPHATE ION, ... | Authors: | Abad-Zapatero, C, Wolf, N.W. | Deposit date: | 2018-03-07 | Release date: | 2019-06-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads. Acs Infect Dis., 5, 2019
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2LTH
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![BU of 2lth by Molmil](/molmil-images/mine/2lth) | NMR structure of major ampullate spidroin 1 N-terminal domain at pH 5.5 | Descriptor: | Major ampullate spidroin 1 | Authors: | Otikovs, M, Jaudzems, K, Nordling, K, Landreh, M, Rising, A, Askarieh, G, Knight, S, Johansson, J. | Deposit date: | 2012-05-25 | Release date: | 2013-11-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation. Nat Commun, 5, 2014
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3JB4
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![BU of 3jb4 by Molmil](/molmil-images/mine/3jb4) | Structure of Ljungan virus: insight into picornavirus packaging | Descriptor: | VP0, VP1, VP3 | Authors: | Zhu, L, Wang, X.X, Ren, J.S, Porta, C, Wenham, H, Ekstrom, J.-O, Panjwani, A, Knowles, N.J, Kotecha, A, Siebert, A, Lindberg, M, Fry, E.E, Rao, Z.H, Tuthill, T.J, Stuart, D.I. | Deposit date: | 2015-07-21 | Release date: | 2015-10-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of Ljungan virus provides insight into genome packaging of this picornavirus. Nat Commun, 6, 2015
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6K3B
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![BU of 6k3b by Molmil](/molmil-images/mine/6k3b) | Crystal structure of Lpg2147-Lpg2149 complex | Descriptor: | Lpg2147, Uncharacterized protein | Authors: | Mu, Y, Wang, Y, Han, Y, Li, D, Feng, Y. | Deposit date: | 2019-05-17 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.974 Å) | Cite: | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC. Nat Commun, 11, 2020
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6KFP
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![BU of 6kfp by Molmil](/molmil-images/mine/6kfp) | Crystal structure of MavC ternary complex | Descriptor: | MavC, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 N | Authors: | Mu, Y, Wang, Y, Han, Y, Li, D, Feng, Y. | Deposit date: | 2019-07-08 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC. Nat Commun, 11, 2020
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8A2F
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![BU of 8a2f by Molmil](/molmil-images/mine/8a2f) | Crystal Structure of Ljunganvirus 1 2A protein | Descriptor: | 2A protein | Authors: | von Castelmur, E, Zhu, L, Wang, X, Fry, E, Ren, J, Perrakis, A, Stuart, D.I. | Deposit date: | 2022-06-03 | Release date: | 2023-06-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structural plasticity of 2A proteins in the Parechovirus family To Be Published
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8A2E
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![BU of 8a2e by Molmil](/molmil-images/mine/8a2e) | Crystal Structure of Human Parechovirus 3 2A protein | Descriptor: | 2A protein, GLYCEROL, SULFATE ION | Authors: | von Castelmur, E, Zhu, L, wang, X, Fry, E, Ren, J, Perrakis, A, Stuart, D.I. | Deposit date: | 2022-06-03 | Release date: | 2023-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structural plasticity of 2A proteins in the Parechovirus family. To Be Published
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8A2G
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![BU of 8a2g by Molmil](/molmil-images/mine/8a2g) | Crystal structure of Sebokelevirus 2A2 protein | Descriptor: | 1,2-ETHANEDIOL, 2A2 protein, TETRAETHYLENE GLYCOL | Authors: | Zhu, L, Von Castelmur, E, Whang, X, Ren, J, Fry, E, Perrakis, A, Stuart, D.I. | Deposit date: | 2022-06-03 | Release date: | 2023-06-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Structural plasticity of 2A proteins in the Parechovirus family to be published
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4EGX
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![BU of 4egx by Molmil](/molmil-images/mine/4egx) | Crystal structure of KIF1A CC1-FHA tandem | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Kinesin-like protein KIF1A | Authors: | Yu, J, Huo, L, Yue, Y, Xu, T, Zhang, M, Feng, W. | Deposit date: | 2012-04-02 | Release date: | 2012-10-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A Structure, 20, 2012
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6WOR
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![BU of 6wor by Molmil](/molmil-images/mine/6wor) | |
3V81
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![BU of 3v81 by Molmil](/molmil-images/mine/3v81) | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... | Authors: | Das, K, Martinez, S.E, Arnold, E. | Deposit date: | 2011-12-22 | Release date: | 2012-01-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8503 Å) | Cite: | HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19, 2012
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1MAF
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![BU of 1maf by Molmil](/molmil-images/mine/1maf) | |
8H2X
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![BU of 8h2x by Molmil](/molmil-images/mine/8h2x) | Structure of Acb2 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, p26 | Authors: | Feng, Y, Cao, X.L. | Deposit date: | 2022-10-07 | Release date: | 2023-02-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Bacteriophages inhibit and evade cGAS-like immune function in bacteria. Cell, 186, 2023
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8H39
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![BU of 8h39 by Molmil](/molmil-images/mine/8h39) | Structure of Acb2 complexed with c-di-AMP | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, 1,2-ETHANEDIOL, p26 | Authors: | Feng, Y, Cao, X.L. | Deposit date: | 2022-10-08 | Release date: | 2023-02-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Bacteriophages inhibit and evade cGAS-like immune function in bacteria. Cell, 186, 2023
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8H2J
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![BU of 8h2j by Molmil](/molmil-images/mine/8h2j) | Structure of Acb2 complexed with 3',3'-cGAMP | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, p26 | Authors: | Feng, Y, Cao, X.L. | Deposit date: | 2022-10-06 | Release date: | 2023-02-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Bacteriophages inhibit and evade cGAS-like immune function in bacteria. Cell, 186, 2023
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1VQJ
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![BU of 1vqj by Molmil](/molmil-images/mine/1vqj) | GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 (V35I) | Descriptor: | GENE V PROTEIN | Authors: | Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. | Deposit date: | 1996-08-14 | Release date: | 1997-02-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
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1VQA
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![BU of 1vqa by Molmil](/molmil-images/mine/1vqa) | |
1VQH
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![BU of 1vqh by Molmil](/molmil-images/mine/1vqh) | |