9E6T
 
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9C12
 | | Leukotriene C4-bound Multidrug Resistance-associated Protein 2 (MRP2) | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, ATP-binding cassette sub-family C member 2, CHOLESTEROL, ... | | Authors: | Koide, E, Chen, J. | | Deposit date: | 2024-05-28 | | Release date: | 2024-12-18 | | Last modified: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2.
Nat Commun, 16, 2025
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9D7I
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 KN Fabs bound | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab light chain, ... | | Authors: | Parsons, R.J, Acharya, P. | | Deposit date: | 2024-08-16 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7H
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 KN Fab bound | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab light chain, ... | | Authors: | Parsons, R.J, Acharya, P. | | Deposit date: | 2024-08-16 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7G
 | | BG505 DS-SOSIP.664 apo structure from the CH103 KN cryo-EM dataset | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Surface protein gp120, ... | | Authors: | Parsons, R.J, Acharya, P. | | Deposit date: | 2024-08-16 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7O
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 Fab bound | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab heavy chain, ... | | Authors: | Parsons, R.J, Acharya, P. | | Deposit date: | 2024-08-16 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7P
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 Fabs bound | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab heavy chain, ... | | Authors: | Parsons, R.J, Acharya, P. | | Deposit date: | 2024-08-16 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9C6M
 | | Yasminevirus c12orf29, a 5' to 3' RNA ligase, K73M mutant | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, RNA ligase1 | | Authors: | Hu, Y, Lopez, V.A, Tagliabracci, V.S, Tomchick, D.R. | | Deposit date: | 2024-06-07 | | Release date: | 2024-10-02 | | Last modified: | 2025-03-05 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9C6L
 | | Yasminevirus c12orf29, a 5' to 3' RNA ligase | | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, RNA ligase1, ... | | Authors: | Hu, Y, Lopez, V.A, Tagliabracci, V.S, Tomchick, D.R. | | Deposit date: | 2024-06-07 | | Release date: | 2024-10-02 | | Last modified: | 2025-03-05 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9F3Y
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9F3X
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9EUU
 | | Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo | | Descriptor: | Alpha-synuclein | | Authors: | Burger, D, Kashyrina, M, Lewis, A, De Nuccio, F, Mohammed, I, de La Seigliere, H, van den Heuvel, L, Feuillie, C, Verchere, J, Berbon, M, Arotcarena, M, Retailleau, A, Bezard, E, Laferriere, F, Loquet, A, Bousset, L, Baron, T, Lofrumento, D.D, De Giorgi, F, Stahlberg, H, Ichas, F. | | Deposit date: | 2024-03-28 | | Release date: | 2024-06-05 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (1.93 Å) | | Cite: | 1.94 angstrom structure of synthetic alpha-synuclein fibrils seeding MSA neuropathology
Biorxiv, 2024
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9DIK
 | | Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM681 (N-cyclopropyl-1,4-dimethyl-5-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazole-3-carboxamide) | | Descriptor: | 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | | Authors: | Deng, X, Tomchick, D, Phillips, M. | | Deposit date: | 2024-09-05 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
J.Med.Chem., 68, 2025
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9DIZ
 | | Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM959 (6-cyclopropyl-2,4-dimethyl-3-((6-(trifluoromethyl)pyridin-3-yl)methyl)-2,6-dihydro-7H-pyrazolo[3,4-c]pyridin-7-one) | | Descriptor: | 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, 6-cyclopropyl-2,4-dimethyl-3-{[6-(trifluoromethyl)pyridin-3-yl]methyl}-2,6-dihydro-7H-pyrazolo[3,4-c]pyridin-7-one, Dihydroorotate dehydrogenase (quinone), ... | | Authors: | Deng, X, Tomchick, D, Phillips, M. | | Deposit date: | 2024-09-06 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
J.Med.Chem., 68, 2025
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9CA5
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9CA6
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9F18
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9EQF
 | | Crystal structure of the L-arginine hydroxylase VioC MeHis316, bound to Fe(II), L-arginine, and succinate | | Descriptor: | 1,2-ETHANEDIOL, ARGININE, Alpha-ketoglutarate-dependent L-arginine hydroxylase, ... | | Authors: | Hardy, F.J. | | Deposit date: | 2024-03-21 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code.
Acs Catalysis, 14, 2024
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9ETK
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9EVD
 | | In situ structure of the peripheral stalk of the mitochondrial ATPsynthase in whole Polytomella cells | | Descriptor: | ASA-10: Polytomella F-ATP synthase associated subunit 10, ASA-9: Polytomella F-ATP synthase associated subunit 9, ATP synthase associated protein ASA1, ... | | Authors: | Dietrich, L, Agip, A.N.A, Kuehlbrandt, W. | | Deposit date: | 2024-03-29 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells.
Science, 385, 2024
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9F5U
 | | Crystal structure of Heme-Oxygenase from Corynebacterium diphtheriae complexed with Cobalt-porphyrine (HumO-Co(III)) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, CITRIC ACID, ... | | Authors: | Labidi, R.J, Faivre, B, Carpentier, P, Perard, J, Gotico, P, Li, Y, Atta, M, Fontecave, M. | | Deposit date: | 2024-04-30 | | Release date: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Light-Activated Artificial CO 2 -Reductase: Structure and Activity.
J.Am.Chem.Soc., 2024
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9F66
 | | Crystal structure of Heme-Oxygenase from Corynebacterium diphtheriae complexed with Cobalt-porphyrine (HumO-Co(III)) flash-cooled under CO2 pressure | | Descriptor: | 1,2-ETHANEDIOL, CARBON DIOXIDE, CHLORIDE ION, ... | | Authors: | Labidi, R.J, Faivre, B, Carpentier, P, Perard, J, Gotico, P, Li, Y, Atta, M, Fontecave, M. | | Deposit date: | 2024-04-30 | | Release date: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Light-Activated Artificial CO 2 -Reductase: Structure and Activity.
J.Am.Chem.Soc., 2024
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8RLY
 | | E. coli endonuclease IV complexed with sulfate, catalytic Fe2+ | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Endonuclease 4, ... | | Authors: | Saper, M.A, Paterson, N.G, Kirillov, S, Rouvinski, A. | | Deposit date: | 2024-01-04 | | Release date: | 2024-12-11 | | Last modified: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Octahedral Iron in Catalytic Sites of Endonuclease IV from Staphylococcus aureus and Escherichia coli .
Biochemistry, 64, 2025
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8RNZ
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8RL2
 | | Human pre-60S - State 5 | | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Thoms, M, Denk, T, Beckmann, R. | | Deposit date: | 2024-01-02 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits.
Nucleic Acids Res., 53, 2025
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