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6YSQ
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BU of 6ysq by Molmil
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Descriptor: Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ...
Authors:Zarantonello, A, Laursen, N.S, Andersen, G.R.
Deposit date:2020-04-23
Release date:2020-06-24
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
J Immunol., 205, 2020
7Q5Z
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BU of 7q5z by Molmil
Cryo-EM structure of native human A2ML1
Descriptor: Alpha-2-macroglobulin-like protein 1
Authors:Zarantonello, A, Nielsen, N.S, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q1Y
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BU of 7q1y by Molmil
X-ray structure of human A2ML1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ...
Authors:Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S.
Deposit date:2021-10-22
Release date:2022-04-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q60
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BU of 7q60 by Molmil
Structure of TEV cleaved A2ML1 (A2ML1-TE)
Descriptor: Alpha-2-macroglobulin-like protein 1
Authors:Nielsen, N.S, Zarantonello, A, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q62
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BU of 7q62 by Molmil
Structure of TEV cleaved A2ML1 dimer (A2ML1-TT dimer)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1
Authors:Nielsen, N.S, Zarantonello, A, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q61
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BU of 7q61 by Molmil
Structure of TEV conjugated A2ML1 (A2ML1-TC)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1
Authors:Nielsen, N.S, Zarantonello, A, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
6XZU
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BU of 6xzu by Molmil
Complex of C-terminal domain of murine complement C3b with the hC3Nb3 nanobody
Descriptor: Complement C3, nanobody hC3Nb1
Authors:Andersen, G.R, Pedersen, H.
Deposit date:2020-02-05
Release date:2020-08-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.
J Immunol., 205, 2020
6Z6V
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BU of 6z6v by Molmil
Globular head of C1q in complex with the nanobody C1qNb75
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, ...
Authors:Laursen, N.S, Andersen, G.R.
Deposit date:2020-05-29
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Front Immunol, 11, 2020

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数据于2024-10-30公开中

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