4YXT
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4YXV
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3DBS
| Structure of PI3K gamma in complex with GDC0941 | Descriptor: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Authors: | Wiesmann, C, Ultsch, M. | Deposit date: | 2008-06-02 | Release date: | 2008-06-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer J.Med.Chem., 51, 2008
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5DZA
| Streptococcus agalactiae AgI/II polypeptide BspA C terminal domain (WT) | Descriptor: | 1,2-ETHANEDIOL, BspA, DI(HYDROXYETHYL)ETHER | Authors: | Rego, S, Till, M, Race, P.R. | Deposit date: | 2015-09-25 | Release date: | 2016-06-22 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structural and Functional Analysis of Cell Wall-anchored Polypeptide Adhesin BspA in Streptococcus agalactiae. J.Biol.Chem., 291, 2016
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5DZ9
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5DZ8
| Streptococcus agalactiae AgI/II polypeptide BspA variable (V) domain | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, BspA (BspA_V), ... | Authors: | Rego, S, Till, M, Race, P.R. | Deposit date: | 2015-09-25 | Release date: | 2016-06-22 | Last modified: | 2016-08-10 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural and Functional Analysis of Cell Wall-anchored Polypeptide Adhesin BspA in Streptococcus agalactiae. J.Biol.Chem., 291, 2016
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4Q1G
| Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-branching | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Polyketide biosynthesis enoyl-CoA isomerase PksI | Authors: | Nair, A.V, Race, P.R, Till, M. | Deposit date: | 2014-04-03 | Release date: | 2015-05-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-methyl branch incorporation. Sci Rep, 10, 2020
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4Q1H
| Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-branching | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Polyketide biosynthesis enoyl-CoA isomerase PksI, ... | Authors: | Nair, A.V, Race, P.R, Till, M. | Deposit date: | 2014-04-03 | Release date: | 2015-05-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-methyl branch incorporation. Sci Rep, 10, 2020
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4Q1K
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4Q1J
| Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-branching | Descriptor: | 1,2-ETHANEDIOL, Polyketide biosynthesis enoyl-CoA isomerase PksI, SODIUM ION | Authors: | Nair, A.V, Race, P.R, Till, M. | Deposit date: | 2014-04-03 | Release date: | 2015-05-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-methyl branch incorporation. Sci Rep, 10, 2020
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4Q1I
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