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Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
Descriptor:	ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ...
Authors:	Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J.
Deposit date:	2019-04-15
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening To Be Published

Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
Descriptor:	Serine/threonine-protein kinase WNK3, ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate
Authors:	Akella, R, Goldsmith, E.J.
Deposit date:	2022-09-04
Release date:	2023-03-01
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (3.111 Å)
Cite:	Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening. Drug Des Devel Ther, 17, 2023

Acinetobacter baumannii dihydroorotate dehydrogenase bound with inhibitor DSM186
Descriptor:	(4R)-7-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ...
Authors:	Deng, X, Phillips, M, Tomchick, D.
Deposit date:	2022-04-26
Release date:	2022-12-28
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119, 2022