1CTN
 
 | | CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION | | Descriptor: | CHITINASE A | | Authors: | Perrakis, A, Tews, I, Dauter, Z, Wilson, K.S, Vorgias, C.E. | | Deposit date: | 1994-10-10 | | Release date: | 1995-02-07 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of a bacterial chitinase at 2.3 A resolution.
Structure, 2, 1994
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6QCG
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8ARF
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1VYB
 | | Endonuclease domain of human LINE1 ORF2p | | Descriptor: | GLYCEROL, ORF2 CONTAINS A REVERSE TRANSCRIPTASE DOMAIN, SULFATE ION, ... | | Authors: | Weichenrieder, O, Repanas, K, Perrakis, A. | | Deposit date: | 2004-04-25 | | Release date: | 2004-06-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.
Structure, 12, 2004
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5IJQ
 | | Crystal structure of autotaxin (ENPP2) re-refined | | Descriptor: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | | Deposit date: | 2016-03-02 | | Release date: | 2016-06-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
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7Z3K
 | | Autotaxin in complex with orthosteric site-binder CpdA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | Authors: | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | | Deposit date: | 2022-03-02 | | Release date: | 2023-01-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Autotaxin facilitates selective LPA receptor signaling.
Cell Chem Biol, 30, 2023
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7Z3L
 | | Autotaxin in complex with hybrid compound ziritaxestat (GLPG1690) | | Descriptor: | 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | | Deposit date: | 2022-03-02 | | Release date: | 2023-01-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Autotaxin facilitates selective LPA receptor signaling.
Cell Chem Biol, 30, 2023
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1EPU
 | | X-RAY crystal structure of neuronal SEC1 from squid | | Descriptor: | S-SEC1 | | Authors: | Bracher, A, Perrakis, A, Dresbach, T, Betz, H, Weissenhorn, W. | | Deposit date: | 2000-03-29 | | Release date: | 2000-08-09 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis.
Structure Fold.Des., 8, 2000
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6NVQ
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7P0K
 | | Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand | | Descriptor: | 2-[[2-ethyl-6-[4-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-2,3-dihydro-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Salgado-Polo, F, Shao, T, Xiao, Z, Van, R, Chen, J, Rong, J, Haider, A, Shao, Y, Josephson, L, Perrakis, A, Liang, S.H. | | Deposit date: | 2021-06-29 | | Release date: | 2022-07-13 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands
J Med Chem, 64, 2021
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4PG9
 | | MHC Class I in complex with Sendai virus nucleoprotein peptide FAPGNYPAL | | Descriptor: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | Authors: | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | Deposit date: | 2014-05-01 | | Release date: | 2015-01-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGE
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAW | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | Deposit date: | 2014-05-01 | | Release date: | 2015-01-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGD
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAF | | Descriptor: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | Authors: | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | Deposit date: | 2014-05-01 | | Release date: | 2015-01-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGB
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNWPAL | | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Celie, P.H.N, Joosten, R.P, Perrakis, A, Neefjes, J. | | Deposit date: | 2014-05-01 | | Release date: | 2015-01-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGC
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGN(3,5-diiodotyrosine)PAL | | Descriptor: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | Authors: | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | Deposit date: | 2014-05-01 | | Release date: | 2015-01-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5IJS
 | | Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | | Deposit date: | 2016-03-02 | | Release date: | 2016-06-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
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7Z5G
 | | human apo MATCAP | | Descriptor: | Uncharacterized protein KIAA0895-like | | Authors: | Bak, J, Adamoupolos, A, Heidebrecht, T, Perrakis, A. | | Deposit date: | 2022-03-09 | | Release date: | 2022-05-11 | | Last modified: | 2022-06-01 | | Method: | X-RAY DIFFRACTION (2.113 Å) | | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
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7Z5H
 | | human Zn MATCAP | | Descriptor: | Uncharacterized protein KIAA0895-like, ZINC ION | | Authors: | Bak, J, Adamopoulos, A, Heidebrecht, T, Perrakis, A. | | Deposit date: | 2022-03-09 | | Release date: | 2022-05-11 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
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3KJY
 | | Crystal structure of reduced HOMO SAPIENS CLIC3 | | Descriptor: | Chloride intracellular channel protein 3, SULFATE ION | | Authors: | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | | Deposit date: | 2009-11-04 | | Release date: | 2009-11-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
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7Z6S
 | | MATCAP bound to a human 14 protofilament microtubule | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Bak, J, Perrakis, A. | | Deposit date: | 2022-03-14 | | Release date: | 2022-05-11 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
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4BRY
 | | The Idas:Geminin heterodimeric parallel coiled-coil | | Descriptor: | GEMININ, MULTICILIN, PHOSPHATE ION, ... | | Authors: | Caillat, C, Perrakis, A. | | Deposit date: | 2013-06-06 | | Release date: | 2013-10-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer that Inhibits Geminin Function in DNA Replication Licensing
J.Biol.Chem., 288, 2013
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7Z0N
 | | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators | | Descriptor: | CALCIUM ION, GLYCEROL, IODIDE ION, ... | | Authors: | Salgado-Polo, F, Clark, J.M, Macdonald, S.J.F, Barrett, T.N, Perrakis, A, Jamieson, A. | | Deposit date: | 2022-02-23 | | Release date: | 2022-05-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.
J.Med.Chem., 65, 2022
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2CKL
 | | Ring1b-Bmi1 E3 catalytic domain structure | | Descriptor: | IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ... | | Authors: | Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K. | | Deposit date: | 2006-04-20 | | Release date: | 2006-05-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
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6FPV
 | | A llama-derived JBP1-targeting nanobody | | Descriptor: | GLYCEROL, Nanobody | | Authors: | van Beusekom, B, Adamopoulos, A, Heidebrecht, T, Joosten, R.P, Perrakis, A. | | Deposit date: | 2018-02-12 | | Release date: | 2018-10-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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3G73
 | | Structure of the FOXM1 DNA binding | | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ... | | Authors: | Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H. | | Deposit date: | 2009-02-09 | | Release date: | 2009-03-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
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