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Formylmethanofuran:tetrahydromethanopterin formyltransferase from Archaeoglobus fulgidus
Descriptor:	Formylmethanofuran--tetrahydromethanopterin formyltransferase, POTASSIUM ION
Authors:	Mamat, B, Roth, A, Grimm, C, Ermler, U, Tziatzios, C, Schubert, D, Thauer, R.K, Shima, S.
Deposit date:	2002-07-09
Release date:	2002-07-26
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship. Protein Sci., 11, 2002

1M5S

Formylmethanofuran:tetrahydromethanopterin fromyltransferase from Methanosarcina barkeri
Descriptor:	Formylmethanofuran--tetrahydromethanopterin formyltransferase
Authors:	Mamat, B, Roth, A, Grimm, C, Ermler, U, Tziatzios, C, Schubert, D, Thauer, R.K, Shima, S.
Deposit date:	2002-07-10
Release date:	2002-07-26
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship. Protein Sci., 11, 2002

3FH7

Leukotriene A4 Hydrolase complexed with inhibitor 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate.
Descriptor:	4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate, ACETATE ION, GLYCEROL, ...
Authors:	Mamat, B, Davies, D.R.
Deposit date:	2008-12-08
Release date:	2010-01-05
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010

3FH5

Leukotriene A4 Hydrolase complexed with inhibitor (2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine.
Descriptor:	(2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine, ACETATE ION, GLYCEROL, ...
Authors:	Mamat, B, Davies, D.R.
Deposit date:	2008-12-08
Release date:	2010-01-05
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.63 Å)
Cite:	Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010

3FH8

Leukotriene A4 Hydrolase complexed with inhibitor 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine.
Descriptor:	1-[2-(4-benzylphenoxy)ethyl]pyrrolidine, ACETATE ION, IMIDAZOLE, ...
Authors:	Mamat, B, Davies, D.R.
Deposit date:	2008-12-09
Release date:	2010-01-05
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.67 Å)
Cite:	Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010

3FHE

Leukotriene A4 Hydrolase complexed with inhibitor N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine.
Descriptor:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:	Mamat, B, Davies, D.R.
Deposit date:	2008-12-09
Release date:	2010-01-05
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.16 Å)
Cite:	Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010

2B0J

The crystal structure of the apoenzyme of the iron-sulfur-cluster-free hydrogenase (Hmd)
Descriptor:	5,10-methenyltetrahydromethanopterin hydrogenase
Authors:	Pilak, O, Mamat, B, Vogt, S, Hagemeier, C.H, Thauer, R.K, Shima, S, Vonrhein, C, Warkentin, E, Ermler, U.
Deposit date:	2005-09-14
Release date:	2006-04-18
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	The Crystal Structure of the Apoenzyme of the Iron-Sulphur Cluster-free Hydrogenase J.Mol.Biol., 358, 2006

1JAX

Structure of Coenzyme F420H2:NADP+ Oxidoreductase (FNO)
Descriptor:	MAGNESIUM ION, SODIUM ION, conserved hypothetical protein
Authors:	Warkentin, E, Mamat, B, Thauer, R, Ermler, U, Shima, S.
Deposit date:	2001-06-01
Release date:	2001-12-21
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound. EMBO J., 20, 2001

1JAY

Structure of Coenzyme F420H2:NADP+ Oxidoreductase (FNO) with its substrates bound
Descriptor:	COENZYME F420, Coenzyme F420H2:NADP+ Oxidoreductase (FNO), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:	Warkentin, E, Mamat, B, Thauer, R, Ermler, U, Shima, S.
Deposit date:	2001-06-01
Release date:	2001-12-21
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound. EMBO J., 20, 2001

3FTS

Leukotriene A4 hydrolase in complex with resveratrol
Descriptor:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.33 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FU6

Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2-ylphenyl)methanamine
Descriptor:	1-(4-thiophen-2-ylphenyl)methanamine, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUN

Leukotriene A4 hydrolase in complex with {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone
Descriptor:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.58 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FTW

Leukotriene A4 hydrolase in complex with fragments N-(pyridin-3-ylmethyl)aniline and acetate
Descriptor:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUD

Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2-ylphenyl)methanamine
Descriptor:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FTY

Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine
Descriptor:	3-(BENZYLOXY)PYRIDIN-2-AMINE, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUF

Leukotriene A4 hydrolase in complex with fragment 5-fluoroindole and bestatin
Descriptor:	2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-fluoro-1H-indole, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FU3

Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol
Descriptor:	4-(2-amino-1,3-thiazol-4-yl)phenol, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUK

Leukotriene A4 hydrolase in complex with 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid
Descriptor:	1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FTX

Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin
Descriptor:	2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol, ACETATE ION, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUI

Leukotriene A4 hydrolase in complex with N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline
Descriptor:	IMIDAZOLE, Leukotriene A-4 hydrolase, N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FU0

Leukotriene A4 hydrolase in complex with fragment 4-(4-fluorobenzoyl)pyridine
Descriptor:	(4-fluorophenyl)(pyridin-4-yl)methanone, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUH

Leukotriene A4 hydrolase in complex with fragment 5-hydroxyindole and bestatin
Descriptor:	1H-indol-5-ol, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FU5

Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2-yl)methylamine
Descriptor:	1-(2,2'-bithiophen-5-yl)methanamine, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUJ

Leukotriene A4 hydrolase in complex with 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole
Descriptor:	5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole, ACETATE ION, IMIDAZOLE, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-14
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FTV

Leukotriene A4 hydrolase in complex with fragment N-(pyridin-3-ylmethyl)aniline
Descriptor:	IMIDAZOLE, Leukotriene A-4 hydrolase, N-(pyridin-3-ylmethyl)aniline, ...
Authors:	Davies, D.R.
Deposit date:	2009-01-13
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

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