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Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
Descriptor:	Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE
Authors:	Ward, Y.D, Thomson, D.S, Frye, L.L, Cywin, C.L, Morwick, T, Emmanuel, M.J, Zindell, R, McNeil, D, Bekkali, Y, Giradot, M, Hrapchak, M, DeTuri, M, Crane, K, White, D, Pav, S, Wang, Y, Hao, M.H, Grygon, C.A, Labadia, M.E, Freeman, D.M, Davidson, W, Hopkins, J.L, Brown, M.L, Spero, D.M.
Deposit date:	2002-09-19
Release date:	2003-04-22
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors J.Med.Chem., 45, 2002

Crystal structure of human Pim-1 in complex with DAPPA
Descriptor:	(2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, Proto-oncogene serine/threonine-protein kinase Pim-1
Authors:	Qian, K.
Deposit date:	2008-10-29
Release date:	2009-03-10
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J.Med.Chem., 52, 2009

HUMAN P38 MAP KINASE INHIBITOR COMPLEX
Descriptor:	4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE, P38 MAP KINASE
Authors:	Tong, L.
Deposit date:	1997-03-07
Release date:	1998-05-06
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat.Struct.Biol., 4, 1997