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The structure of a three-way DNA junction in complex with a metallo-supramolecular helicate reveals a new target for drugs
Descriptor:	5'-D(CPGPTPAPCPG)-3', FE (II) ION, N-[(1E)-PYRIDIN-2-YLMETHYLENE]-N-[4-(4-{[(1E)-PYRIDIN-2-YLMETHYLENE]AMINO}BENZYL)PHENYL]AMINE
Authors:	Oleksi, A, Blanco, A.G, Boer, R, Uson, I, Aymami, J, Coll, M.
Deposit date:	2005-10-27
Release date:	2006-03-14
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Molecular Recognition of a Three-Way DNA Junction by a Metallosupramolecular Helicate ANGEW.CHEM.INT.ED.ENGL., 45, 2006

CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
Descriptor:	2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5
Authors:	McMillan, B.J, McKinney, D.C, Timm, D.E.
Deposit date:	2021-03-10
Release date:	2021-03-17
Last modified:	2021-08-25
Method:	ELECTRON MICROSCOPY (2.39 Å)
Cite:	Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021

Abortive infection DNA polymerase AbiA from Lactococcus lactis
Descriptor:	AbiA, DNA (5'-D(APAPAPAPAPAPAPAP*T)-3'), MAGNESIUM ION
Authors:	Gapinska, M.A, Nowotny, M.
Deposit date:	2023-05-08
Release date:	2024-04-03
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Structure-functional characterization of Lactococcus AbiA phage defense system. Nucleic Acids Res., 52, 2024