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Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar
Descriptor:	CHOLESTEROL, If kappa light chain, MRK16 Fab-fragment heavy chain, ...
Authors:	Nosol, K, Locher, K.P.
Deposit date:	2020-08-25
Release date:	2020-10-14
Last modified:	2020-10-28
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc.Natl.Acad.Sci.USA, 117, 2020

Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (apo-inward-open conformation)
Descriptor:	4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, CHOLESTEROL, ...
Authors:	Nosol, K, Locher, K.P.
Deposit date:	2021-02-14
Release date:	2021-08-25
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021

Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation)
Descriptor:	1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment light chain, CHOLESTEROL, ...
Authors:	Nosol, K, Locher, K.P.
Deposit date:	2021-02-14
Release date:	2021-08-25
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021

Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation)
Descriptor:	1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, ...
Authors:	Nosol, K, Locher, K.P.
Deposit date:	2021-02-14
Release date:	2021-08-25
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021