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7B49
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BU of 7b49 by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ...
Authors:Rozenberg, H, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4G
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BU of 7b4g by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II)
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ...
Authors:Degtjarik, O, Rozenberg, H, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4F
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BU of 7b4f by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)
Descriptor: Cellular tumor antigen p53, DNA target, FORMIC ACID, ...
Authors:Rozenberg, H, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4B
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BU of 7b4b by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I)
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ...
Authors:Degtjarik, O, Rozenberg, H, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4A
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BU of 7b4a by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA
Descriptor: Cellular tumor antigen p53, DNA target, FORMIC ACID, ...
Authors:Golovenko, D, Rozenberg, H, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
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