3GCA
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3GS8
| An all-RNA hairpin ribozyme A38N1dA38 variant with a transition-state mimic substrate strand | 分子名称: | 2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL DIHYDROGEN PHOSPHATE, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3'), ... | 著者 | Spitale, R.C, Volpini, R, Heller, M.G, Krucinska, J, Cristalli, G, Wedekind, J.E. | 登録日 | 2009-03-26 | 公開日 | 2009-04-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Identification of an imino group indispensable for cleavage by a small ribozyme. J.Am.Chem.Soc., 131, 2009
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3GS1
| An all-RNA Hairpin Ribozyme with mutation A38N1dA | 分子名称: | 2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL DIHYDROGEN PHOSPHATE, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3'), ... | 著者 | Spitale, R.C, Volpini, R, Heller, M.G, Krucinska, J, Cristalli, G, Wedekind, J.E. | 登録日 | 2009-03-26 | 公開日 | 2009-05-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Identification of an imino group indispensable for cleavage by a small ribozyme. J.Am.Chem.Soc., 131, 2009
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3GS5
| An all-RNA hairpin ribozyme A38N1dA variant with a product mimic substrate strand | 分子名称: | 2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL DIHYDROGEN PHOSPHATE, COBALT HEXAMMINE(III), RNA (25-MER), ... | 著者 | Spitale, R.C, Volpini, R, Heller, M.G, Krucinska, J, Cristalli, G, Wedekind, J.E. | 登録日 | 2009-03-26 | 公開日 | 2009-04-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Identification of an imino group indispensable for cleavage by a small ribozyme. J.Am.Chem.Soc., 131, 2009
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3I2R
| Crystal structure of the hairpin ribozyme with a 2',5'-linked substrate with N1-deazaadenosine at position A9 | 分子名称: | 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3', COBALT HEXAMMINE(III), ... | 著者 | Wedekind, J.E, Spitale, R.C, Krucinska, J. | 登録日 | 2009-06-29 | 公開日 | 2009-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core. Biochemistry, 48, 2009
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3I2Q
| Crystal structure of the hairpin ribozyme with 2'OMe substrate strand and N1-deazaadenosine at position A9 | 分子名称: | 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*GP*U)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3', COBALT HEXAMMINE(III), ... | 著者 | Wedekind, J.E, Spitale, R.C, Krucinska, J. | 登録日 | 2009-06-29 | 公開日 | 2009-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core. Biochemistry, 48, 2009
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3I2U
| Crystal structure of the haiprin ribozyme with a 2',5'-linked substrate and N1-deazaadenosine at position A10 | 分子名称: | 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3', COBALT HEXAMMINE(III), ... | 著者 | Wedekind, J.E, Spitale, R.C, Krucinska, J. | 登録日 | 2009-06-29 | 公開日 | 2009-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core. Biochemistry, 48, 2009
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3I2S
| Crystal structure of the hairpin ribozyme with a 2'OMe substrate and N1-deazaadenosine at position A10 | 分子名称: | 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*GP*U)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3', COBALT HEXAMMINE(III), ... | 著者 | Wedekind, J.E, Spitale, R.C, Krucinska, J. | 登録日 | 2009-06-29 | 公開日 | 2009-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core. Biochemistry, 48, 2009
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3CQS
| A 3'-OH, 2',5'-phosphodiester substitution in the hairpin ribozyme active site reveals similarities with protein ribonucleases | 分子名称: | 13-mer substrate strand with 3'-OH, 2',5'-phosphodiester covalently linking 5th and 6th nucleotides, 19-mer ribozyme strand, ... | 著者 | Torelli, A.T, Spitale, R.C, Krucinska, J, Wedekind, J.E. | 登録日 | 2008-04-03 | 公開日 | 2008-05-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Shared traits on the reaction coordinates of ribonuclease and an RNA enzyme Biochem.Biophys.Res.Commun., 371, 2008
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6N55
| Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine | 分子名称: | 2'-azido-2'-deoxyuridine, GLYCEROL, PHOSPHATE ION, ... | 著者 | Cuthbert, B.J, Nainar, S, Spitale, R.C, Goulding, C.W. | 登録日 | 2018-11-21 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.085 Å) | 主引用文献 | An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. Nat.Methods, 17, 2020
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6N54
| Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidocytidine monophosphate | 分子名称: | 2'-azido-2'-deoxycytidine 5'-(dihydrogen phosphate), GLYCEROL, MAGNESIUM ION, ... | 著者 | Cuthbert, B.J, Nainar, S, Spitale, R.C, Goulding, C.W. | 登録日 | 2018-11-21 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.424 Å) | 主引用文献 | An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. Nat.Methods, 17, 2020
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6N53
| Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine monophosphate | 分子名称: | 2'-deoxy-2'-triaza-1,2-dien-2-ium-1-yl-uridine-5'-monophosphate, GLYCEROL, MAGNESIUM ION, ... | 著者 | Cuthbert, B.J, Nainar, S, Spitale, R.C, Goulding, C.W. | 登録日 | 2018-11-21 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. Nat.Methods, 17, 2020
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4RZD
| Crystal Structure of a PreQ1 Riboswitch | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, PreQ1-III Riboswitch (Class 3) | 著者 | Wedekind, J.E, Liberman, J.A, Salim, M. | 登録日 | 2014-12-20 | 公開日 | 2015-07-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proc.Natl.Acad.Sci.USA, 112, 2015
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6PWZ
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2NPZ
| Crystal structure of junctioned hairpin ribozyme incorporating synthetic propyl linker | 分子名称: | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', ... | 著者 | MacElrevey, C, Krucinska, J, Wedekind, J.E. | 登録日 | 2006-10-30 | 公開日 | 2007-08-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme. Acta Crystallogr.,Sect.D, 63, 2007
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2NPY
| Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1 | 分子名称: | 2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL DIHYDROGEN PHOSPHATE, 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', ... | 著者 | MacElrevey, C, Krucinska, J, Wedekind, J.E. | 登録日 | 2006-10-30 | 公開日 | 2007-08-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme. Acta Crystallogr.,Sect.D, 63, 2007
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3Q51
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3Q50
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