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Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole
分子名称:	1-[3-(4-chloro-3,5-dimethylphenoxy)benzyl]-1H-imidazole, PROTOPORPHYRIN IX CONTAINING FE, Sterol 14-alpha demethylase
著者	Wawrzak, Z, Hargrove, T.Y, Pollastri, M.P, Lepesheva, G.I.
登録日	2012-09-19
公開日	2013-03-20
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth. J.Med.Chem., 56, 2013

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor
分子名称:	2-[2-[[3-(1~{H}-benzimidazol-2-ylamino)propylamino]methyl]-4,6-bis(chloranyl)indol-1-yl]ethanol, GLYCEROL, METHIONINE, ...
著者	Barros-Alvarez, X, Hol, W.G.J.
登録日	2016-10-24
公開日	2017-04-12
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis. ACS Infect Dis, 3, 2017