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Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide
分子名称:	2-[(trans-4-hydroxycyclohexyl)amino]-4-[5-(4-phenyl-1H-imidazol-1-yl)isoquinolin-1-yl]benzamide, Heat shock protein HSP 90-alpha
著者	Chong, K.T, Yamashita, S, Oshiumi, H, Uno, T, Kitade, M.
登録日	2014-01-23
公開日	2015-02-25
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Evolution of highly selective Hsp90 / inhibitors by structure and thermodynamics guided design To be Published

Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide
分子名称:	3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide, Heat shock protein HSP 90-alpha
著者	Uno, T, Chong, K.T, Suzuki, T.
登録日	2018-04-23
公開日	2019-01-02
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor. J. Med. Chem., 62, 2019