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Structure of PI3K gamma in complex with an inhibitor
分子名称:	N-[5-(5-methoxypyridin-3-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Collier, P.N, Messersmith, D, Le Tiran, A, Bandarage, U.K, Boucher, C, Come, J, Cottrell, K.M, Damagnez, V, Doran, J.D, Griffith, J.P, Khare-Pandit, S, Krueger, E.B, Ledeboer, M.W, Ledford, B, Liao, Y, Mahajan, S, Moody, C.S, Wang, T, Xu, J, Aronov, A.M.
登録日	2015-01-29
公開日	2015-08-05
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.76 Å)
主引用文献	Structure of PI3K gamma in complex with an inhibitor To Be Published

Structure of PI3K gamma in complex with an inhibitor
分子名称:	N-[5-(6-methoxypyrazin-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Collier, P.N, Messersmith, D, Le Tiran, A, Bandarage, U.K, Boucher, C, Come, J, Cottrell, K.M, Damagnez, V, Doran, J.D, Griffith, J.P, Khare-Pandit, S, Krueger, E.B, Ledeboer, M.W, Ledford, B, Liao, Y, Mahajan, S, Moody, C.S, Wang, T, Xu, J, Aronov, A.M.
登録日	2015-02-03
公開日	2016-02-03
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Structure of PI3K gamma in complex with an inhibitor To Be Published

Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor
分子名称:	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile
著者	Jacobs, M.D, Griffin, J.P.
登録日	2018-01-05
公開日	2018-06-27
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.31 Å)
主引用文献	Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J. Med. Chem., 61, 2018