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Structure of MK2 Complexed with Compound 76
分子名称:	(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, MAP kinase-activated protein kinase 2, STAUROSPORINE
著者	White, A, Wu, J.P, Wang, J, Abeywardane, A, Andersen, D, Emmanuel, M, Gautschi, E, Goldberg, D.R, Kashem, M.A, Lukas, S, Mao, W, Martin, L, Morwick, T, Moss, N, Pargellis, C, Patel, U.R, Patnaude, L, Peet, G.W, Skow, D, Snow, R.J, Ward, Y, Werneburg, B.
登録日	2007-05-18
公開日	2007-07-31
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	The discovery of carboline analogs as potent MAPKAP-K2 inhibitors Bioorg.Med.Chem.Lett., 17, 2007

Crystal structure of human Pim-1 in complex with DAPPA
分子名称:	(2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, Proto-oncogene serine/threonine-protein kinase Pim-1
著者	Qian, K.
登録日	2008-10-29
公開日	2009-03-10
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J.Med.Chem., 52, 2009

Cryo-EM structure of the inner MKLN1 dimer from an autoinhibited MKLN1 tetramer
分子名称:	Muskelin
著者	Chana, C.K, Keszei, A.F.A, Sicheri, F.
登録日	2023-08-14
公開日	2024-09-11
実験手法	ELECTRON MICROSCOPY (3.27 Å)
主引用文献	FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation. Nat Commun, 15, 2024