8KCP
| Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCU
| Cryo-EM structure of human gamma-secretase in complex with MK-0752 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCT
| Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | 分子名称: | (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCS
| Cryo-EM structure of human gamma-secretase in complex with BMS906024 | 分子名称: | (2S,3R)-N'-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis[3,3,3-tris(fluoranyl)propyl]butanediamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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4M9P
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5DCP
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8I3Y
| Crystal structure of ASCT from Trypanosoma brucei in complex with Succinyl-CoA. | 分子名称: | CALCIUM ION, SUCCINIC ACID, SUCCINYL-COENZYME A, ... | 著者 | Mochizuki, K, Inaoka, D.K, Fukuda, K, Kurasawa, H, Iyoda, K, Nakai, U, Harada, S, Balogun, E.O, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Hirayama, K, Kita, K, Shiba, T. | 登録日 | 2023-01-18 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of ASCT from Trypanosoma brucei in complex with Succinyl-CoA. To Be Published
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8I40
| Crystal structure of ASCT from Trypanosoma brucei in complex with CoA. | 分子名称: | ACETATE ION, CALCIUM ION, COENZYME A, ... | 著者 | Mochizuki, K, Inaoka, D.K, Fukuda, K, Kurasawa, H, Iyoda, K, Nakai, U, Harada, S, Balogun, E.O, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Hirayama, K, Kita, K, Shiba, T. | 登録日 | 2023-01-18 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Crystal structure of ligand complexes of ASCT from Trypanosoma brucei and molecular mechanism in comparison with mammalian SCOT. To Be Published
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8PJ9
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8PK1
| Cas1-Cas2 CRISPR integrase bound to prespacer DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, Chains: G,J, ... | 著者 | Sasnauskas, G, Gaizauskaite, U, Tamulaitiene, G. | 登録日 | 2023-06-23 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural basis for spacer acquisition in a type II-A CRISPR-Cas system To Be Published
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8Q2N
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4P3W
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6EW1
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8KCO
| Cryo-EM structure of human gamma-secretase in complex with RO4929097 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 To Be Published
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4MGX
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3V8O
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5NMY
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