Search by PDB author

Potent, selective and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase (HDAC) inhibitors
分子名称:	(1S,2S,3S)-1-fluoranyl-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, SODIUM ION, ...
著者	Luckhurst, C.A, Breccia, P, Stott, A.J, Aziz, O, Birch, H, Burli, R.W, Hughes, S, Jarvis, R.E, Lamers, M, Leonard, P, Matthews, K.L, McAllister, G, Pollack, S, Saville-Stones, E, Wishart, G, Yates, D, Dominguez, C.
登録日	2015-05-22
公開日	2016-02-10
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	Potent, Selective, and Cns-Penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (Hdac) Inhibitors. Acs Med.Chem.Lett., 7, 2016

Structure-based exploration of selectivity for ATM inhibitors in Huntingtons disease
分子名称:	4-morpholin-4-yl-6-[(2~{R})-2-(phenylmethyl)pyrrolidin-1-yl]-1~{H}-pyridin-2-one, Phosphatidylinositol 3-kinase catalytic subunit type 3
著者	Van de Poel, A, Leonard, P.M, Lamers, M.B.A.C.
登録日	2020-04-06
公開日	2021-04-14
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (3.12 Å)
主引用文献	Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease. J.Med.Chem., 64, 2021

Optimization of potent and selective ATM inhibitors suitable for a proof-of-concept study in Huntington's disease models
分子名称:	2-morpholin-4-yl-6-[7-[(2~{R})-1-morpholin-4-ylpropan-2-yl]oxy-9~{H}-thioxanthen-4-yl]pyran-4-one, Phosphatidylinositol 3-kinase catalytic subunit type 3
著者	Leonard, P.M.
登録日	2018-11-07
公開日	2019-03-20
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.09 Å)
主引用文献	Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models. J.Med.Chem., 62, 2019