7TJF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tjf by Molmil](/molmil-images/mine/7tjf) | S. cerevisiae ORC bound to 84 bp ARS1 DNA | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA, 84 bp ARS1, ... | 著者 | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | 登録日 | 2022-01-16 | 公開日 | 2023-01-18 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tjh by Molmil](/molmil-images/mine/7tjh) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | 著者 | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | 登録日 | 2022-01-16 | 公開日 | 2022-10-05 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tji by Molmil](/molmil-images/mine/7tji) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | 著者 | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | 登録日 | 2022-01-16 | 公開日 | 2022-10-05 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tjk by Molmil](/molmil-images/mine/7tjk) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | 著者 | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | 登録日 | 2022-01-16 | 公開日 | 2022-10-05 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tjj by Molmil](/molmil-images/mine/7tjj) | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | 著者 | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | 登録日 | 2022-01-16 | 公開日 | 2022-10-05 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
8STT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8stt by Molmil](/molmil-images/mine/8stt) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) varient in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor | 分子名称: | 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | 著者 | Hollander, K, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|
8STP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8stp by Molmil](/molmil-images/mine/8stp) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) varient in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor | 分子名称: | 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile, Reverse transcriptase/ribonuclease H, p51 RT | 著者 | Hollander, K, Frey, K.M, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|
8STR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8str by Molmil](/molmil-images/mine/8str) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) varient in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a non-nucleoside inhibitor | 分子名称: | 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H, p51 RT | 著者 | Hollander, K, Chan, A.H, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|
8STU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8stu by Molmil](/molmil-images/mine/8stu) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-6-fluoroindolizine-2-carbonitrile (JLJ578), a non-nucleoside inhibitor | 分子名称: | 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | 著者 | Hollander, K, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|
8STV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8stv by Molmil](/molmil-images/mine/8stv) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor | 分子名称: | 1,2-ETHANEDIOL, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, MAGNESIUM ION, ... | 著者 | Hollander, K, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|
8STQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8stq by Molmil](/molmil-images/mine/8stq) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) varient in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor | 分子名称: | 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | 著者 | Hollander, K, Frey, K.M, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.955 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|
8STS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sts by Molmil](/molmil-images/mine/8sts) | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) varient in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a non-nucleoside inhibitor | 分子名称: | 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | 著者 | Hollander, K, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-05-11 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
|
|