6V52
 
 | | IDO1 IN COMPLEX WITH COMPOUND 1 | | 分子名称: | 3-chloro-N-{4-[1-(propylcarbamoyl)cyclobutyl]phenyl}benzamide, Indoleamine 2,3-dioxygenase 1 | | 著者 | Lesburg, C.A, Koenig, K.V, Augustin, M.A. | | 登録日 | 2019-12-03 | | 公開日 | 2020-04-08 | | 最終更新日 | 2020-04-29 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).
Acs Med.Chem.Lett., 11, 2020
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7LUF
 | | HSV1 polymerase ternary complex with dsDNA and PNU-183792 | | 分子名称: | DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ... | | 著者 | Hayes, R.P, Klein, D. | | 登録日 | 2021-02-22 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Nat Commun, 12, 2021
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8T7D
 | | Crystal structure of wild type IDH1 bound to compound 1 | | 分子名称: | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide | | 著者 | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | | 登録日 | 2023-06-20 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (3.444 Å) | | 主引用文献 | Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
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8T7O
 | | Crystal structure of the R132H mutant of IDH1 bound to AG-120 | | 分子名称: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ivosidenib | | 著者 | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | | 登録日 | 2023-06-20 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
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8T7N
 | | Crystal structure of the R132H mutant of IDH1 bound to compound 1 | | 分子名称: | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | | 登録日 | 2023-06-20 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
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8VQ2
 | | HSV1 polymerase ternary complex with dsDNA and compound 44 | | 分子名称: | 2-(4-bromophenyl)-N-(3-methoxy-4-{[(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl}phenyl)acetamide, DNA (5'-D(P*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*T)-3'), ... | | 著者 | Hayes, R.P, Heo, M.R, Plotkin, M. | | 登録日 | 2024-01-17 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (3.829 Å) | | 主引用文献 | Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.
Acs Med.Chem.Lett., 15, 2024
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