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Pyrazole-based Cathepsin S Inhibitors with Arylalkynes as P1 Binding Elements
分子名称:	2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol, Cathepsin S
著者	Bembenek, S.
登録日	2009-07-22
公開日	2009-10-06
最終更新日	2021-10-13
実験手法	X-RAY DIFFRACTION (2.18 Å)
主引用文献	Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements. Bioorg.Med.Chem.Lett., 19, 2009

Crystal structure of human Cathepsin-S with bound ligand
分子名称:	2-[5-[5-ethanoyl-1-[(2~{R})-2-oxidanyl-3-[4-(2-oxidanylpropan-2-yl)piperidin-1-yl]propyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-yl-ethanone, Cathepsin S
著者	Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K.
登録日	2017-08-04
公開日	2017-12-20
最終更新日	2021-11-17
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors. Bioorg.Med.Chem.Lett., 20, 2010