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p53 cancer mutant Y220C with Cys182 alkylation
分子名称:	5-chloranylpyrimidine-4-carboxylic acid, Cellular tumor antigen p53, ZINC ION
著者	Joerger, A.C, Bauer, M.R, Fersht, A.R.
登録日	2016-06-14
公開日	2016-08-10
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc.Natl.Acad.Sci.USA, 113, 2016

1CIR

COMPLEX OF TWO FRAGMENTS OF CI2 [(1-40)(DOT)(41-64)]
分子名称:	CHYMOTRYPSIN INHIBITOR 2
著者	Davis, B.J, Fersht, A.R.
登録日	1995-10-02
公開日	1996-01-29
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism Structure Fold.Des., 1, 1996

1CIQ

COMPLEX OF TWO FRAGMENTS OF CI2, RESIDUES 1-40 AND 41-64
分子名称:	CHYMOTRYPSIN INHIBITOR 2
著者	Buckle, A.M, Fersht, A.R.
登録日	1995-10-02
公開日	1996-03-08
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism Structure Fold.Des., 1, 1996

1FY9

CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN
分子名称:	60 KD CHAPERONIN, GLYCEROL
著者	Wang, Q, Buckle, A.M, Fersht, A.R.
登録日	2000-09-28
公開日	2000-11-22
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Stabilization of GroEL minichaperones by core and surface mutations. J.Mol.Biol., 298, 2000

1FYA

CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN
分子名称:	60 KD CHAPERONIN, GLYCEROL
著者	Wang, Q, Buckle, A.M, Fersht, A.R.
登録日	2000-09-28
公開日	2000-11-22
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Stabilization of GroEL minichaperones by core and surface mutations. J.Mol.Biol., 298, 2000

2J1Z

Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1Y

Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
分子名称:	CALCIUM ION, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.69 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J20

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C
分子名称:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
著者	Joerger, A.C, Ang, H.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1X

Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1W

Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J21

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

4AGO

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174
分子名称:	CELLULAR TUMOR ANTIGEN P53, TERT-BUTYL [3-(3-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-HYDROXY-5-IODOPHENYL)PROP-2-YN-1-YL]CARBAMATE, ZINC ION
著者	Joerger, A.C, Wilcken, R, Fersht, A.R, Boeckler, F.M.
登録日	2012-01-30
公開日	2012-03-21
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012

4AGM

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086
分子名称:	2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4,6-DIIODOPHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日	2012-01-30
公開日	2012-03-21
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.52 Å)
主引用文献	Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012

4AGP

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176
分子名称:	2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-(3-phenoxyprop-1-yn-1-yl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Wilcken, R, Fersht, A.R, Boeckler, F.M.
登録日	2012-01-30
公開日	2012-03-21
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012

4AGL

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784
分子名称:	2,4-BIS(IODANYL)-6-[[METHYL-(1-METHYLPIPERIDIN-4-YL)AMINO]METHYL]PHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日	2012-01-30
公開日	2012-03-21
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012

4AGQ

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196
分子名称:	2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-[3-(phenylamino)prop-1-yn-1-yl]phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日	2012-01-30
公開日	2012-03-21
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012

4AGN

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116
分子名称:	2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-(3-HYDROXYPROP-1-YN-1-YL)-6-IODOPHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日	2012-01-30
公開日	2012-03-21
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012

1B27

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-12-04
公開日	1998-12-09
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

1B2S

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR), SULFATE ION
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-11-30
公開日	1998-12-08
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.82 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

1B3S

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-12-01
公開日	1998-12-09
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.39 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

1B2U

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-12-01
公開日	1998-12-09
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

2BIM

human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H
分子名称:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIQ

human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIN

human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIO

human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

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