5HD7
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![BU of 5hd7 by Molmil](/molmil-images/mine/5hd7) | Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | 分子名称: | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. | 登録日 | 2016-01-04 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
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7WGC
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![BU of 7wgc by Molmil](/molmil-images/mine/7wgc) | Neutral Omicron Spike Trimer in complex with ACE2. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7WG7
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![BU of 7wg7 by Molmil](/molmil-images/mine/7wg7) | Acidic Omicron Spike Trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7WG9
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![BU of 7wg9 by Molmil](/molmil-images/mine/7wg9) | Delta Spike Trimer(1 RBD Up) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7WGB
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![BU of 7wgb by Molmil](/molmil-images/mine/7wgb) | Neutral Omicron Spike Trimer in complex with ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7WG8
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![BU of 7wg8 by Molmil](/molmil-images/mine/7wg8) | Delta Spike Trimer(3 RBD Down) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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1SUA
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![BU of 1sua by Molmil](/molmil-images/mine/1sua) | SUBTILISIN BPN' | 分子名称: | SUBTILISIN BPN', TETRAPEPTIDE ALA-LEU-ALA-LEU | 著者 | Almog, O, Gilliland, G.L. | 登録日 | 1997-01-14 | 公開日 | 1998-01-14 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of calcium-independent subtilisin BPN' with restored thermal stability folded without the prodomain. Proteins, 31, 1998
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7WLC
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![BU of 7wlc by Molmil](/molmil-images/mine/7wlc) | |
7WED
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![BU of 7wed by Molmil](/molmil-images/mine/7wed) | |
7WEA
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![BU of 7wea by Molmil](/molmil-images/mine/7wea) | |
7WE8
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![BU of 7we8 by Molmil](/molmil-images/mine/7we8) | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2021-12-23 | 公開日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
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7WEC
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![BU of 7wec by Molmil](/molmil-images/mine/7wec) | |
7WE7
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![BU of 7we7 by Molmil](/molmil-images/mine/7we7) | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 282, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2021-12-23 | 公開日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
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7WEE
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![BU of 7wee by Molmil](/molmil-images/mine/7wee) | |
7WEF
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![BU of 7wef by Molmil](/molmil-images/mine/7wef) | |
7WEB
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![BU of 7web by Molmil](/molmil-images/mine/7web) | |
7WE9
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![BU of 7we9 by Molmil](/molmil-images/mine/7we9) | |
2KDM
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![BU of 2kdm by Molmil](/molmil-images/mine/2kdm) | NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | 分子名称: | DESIGNED PROTEIN | 著者 | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | 登録日 | 2009-01-12 | 公開日 | 2009-12-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | From the Cover: A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
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2KDL
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![BU of 2kdl by Molmil](/molmil-images/mine/2kdl) | NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | 分子名称: | designed protein | 著者 | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | 登録日 | 2009-01-12 | 公開日 | 2009-12-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
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4EW9
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![BU of 4ew9 by Molmil](/molmil-images/mine/4ew9) | The liganded structure of C. bescii family 3 pectate lyase | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-deoxy-beta-L-threo-hex-4-enopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid, ACETATE ION, ... | 著者 | Alahuhta, P.M, Lunin, V.V. | 登録日 | 2012-04-26 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The structure and mode of action of Caldicellulosiruptor bescii family 3 pectate lyase in biomass deconstruction. Acta Crystallogr. D Biol. Crystallogr., 69, 2013
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2LHE
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![BU of 2lhe by Molmil](/molmil-images/mine/2lhe) | Gb98-T25I,L20A | 分子名称: | Gb98 | 著者 | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | 登録日 | 2011-08-08 | 公開日 | 2012-02-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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2LHG
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![BU of 2lhg by Molmil](/molmil-images/mine/2lhg) | GB98-T25I solution structure | 分子名称: | GB98 | 著者 | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | 登録日 | 2011-08-08 | 公開日 | 2012-02-29 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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2LHC
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![BU of 2lhc by Molmil](/molmil-images/mine/2lhc) | Ga98 solution structure | 分子名称: | Ga98 | 著者 | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | 登録日 | 2011-08-08 | 公開日 | 2012-02-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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7WQR
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![BU of 7wqr by Molmil](/molmil-images/mine/7wqr) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 28 | 分子名称: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ~{N}-(3-chlorophenyl)-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzamide | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-25 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.124 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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7WQS
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![BU of 7wqs by Molmil](/molmil-images/mine/7wqs) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 25 | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-26 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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