5NUH
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6P6G
| Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors | 分子名称: | 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... | 著者 | Elkins, P.A, Wang, L. | 登録日 | 2019-06-03 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
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6P6K
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6P7Z
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6PAF
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6PXV
| Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. | 分子名称: | Insulin, Insulin receptor | 著者 | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | 登録日 | 2019-07-27 | 公開日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
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6PYH
| Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. | 分子名称: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | 著者 | Li, J, Choi, E, Yu, H.T, Bai, X.C. | 登録日 | 2019-07-29 | 公開日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
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6PXW
| Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex. | 分子名称: | Insulin, Insulin receptor | 著者 | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | 登録日 | 2019-07-28 | 公開日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
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6VLB
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6VLC
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6WML
| Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod) | 分子名称: | (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Appleby, T.C, Perry, J.K, Mish, M, Villasenor, A.G, Mackman, R.L. | 登録日 | 2020-04-21 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J.Med.Chem., 63, 2020
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6XTG
| Ab 1116NS19.9 bound to CA19-9 | 分子名称: | Heavy chain, Light chain, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-[alpha-L-fucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Diskin, R, Borenstein-Katz, A. | 登録日 | 2020-01-16 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies. J.Mol.Biol., 433, 2021
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6XUN
| Ab 5b1 bound to CA19-9 | 分子名称: | GLYCEROL, Heavy chain, Light chain, ... | 著者 | Diskin, R, Borenstein-Katz, A. | 登録日 | 2020-01-20 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies. J.Mol.Biol., 433, 2021
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6XUK
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6XUD
| Apo Ab 1116NS19.9 | 分子名称: | Heavy chain, Light chain | 著者 | Diskin, R, Borenstein-Katz, A. | 登録日 | 2020-01-19 | 公開日 | 2021-01-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies. J.Mol.Biol., 433, 2021
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6XUL
| Apo Ab 5b1 | 分子名称: | Heavy chain, Light chain | 著者 | Diskin, R, Borenstein-Katz, A. | 登録日 | 2020-01-20 | 公開日 | 2021-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies. J.Mol.Biol., 433, 2021
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2Q6F
| Crystal structure of infectious bronchitis virus (IBV) main protease in complex with a Michael acceptor inhibitor N3 | 分子名称: | Infectious bronchitis virus (IBV) main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | 著者 | Xue, X.Y, Yang, H.T, Xue, F, Bartlam, M, Rao, Z.H. | 登録日 | 2007-06-05 | 公開日 | 2008-02-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J.Virol., 82, 2008
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2Q6D
| Crystal structure of infectious bronchitis virus (IBV) main protease | 分子名称: | Infectious bronchitis virus (IBV) main protease | 著者 | Xue, X.Y, Yang, H.T, Xue, F, Bartlam, M, Rao, Z.H. | 登録日 | 2007-06-04 | 公開日 | 2008-02-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J.Virol., 82, 2008
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2Q6G
| Crystal structure of SARS-CoV main protease H41A mutant in complex with an N-terminal substrate | 分子名称: | Polypeptide chain, severe acute respiratory syndrome coronavirus (SARS-CoV) | 著者 | Xue, X.Y, Yang, H.T, Xue, F, Bartlam, M, Rao, Z.H. | 登録日 | 2007-06-05 | 公開日 | 2008-02-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J.Virol., 82, 2008
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8IL3
| Cryo-EM structure of CD38 in complex with FTL004 | 分子名称: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain | 著者 | Yang, J, Wang, Y, Zhang, G. | 登録日 | 2023-03-01 | 公開日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J Hematol Oncol, 15, 2022
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1NLP
| STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | C-SRC, NL2 (MN8-MN1-PLPPLP) | 著者 | Feng, S, Kapoor, T.M, Shirai, F, Combs, A.P, Schreiber, S.L. | 登録日 | 1996-08-04 | 公開日 | 1997-01-27 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem.Biol., 3, 1996
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1NLO
| STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | C-SRC, NL1 (MN7-MN2-MN1-PLPPLP) | 著者 | Feng, S, Kapoor, T.M, Shirai, F, Combs, A.P, Schreiber, S.L. | 登録日 | 1996-08-04 | 公開日 | 1997-01-27 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem.Biol., 3, 1996
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1QWE
| C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12 | 分子名称: | ALA-PRO-PRO-LEU-PRO-PRO-ARG-ASN-ARG-PRO-ARG-LEU, TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC | 著者 | Feng, S, Chiyoshi, K, Rickles, R.J, Schreiber, S.L. | 登録日 | 1995-11-09 | 公開日 | 1996-03-08 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc.Natl.Acad.Sci.USA, 92, 1995
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1QWF
| C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12 | 分子名称: | TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC, VAL-SER-LEU-ALA-ARG-ARG-PRO-LEU-PRO-PRO-LEU-PRO | 著者 | Feng, S, Chiyoshi, K, Rickles, R.J, Schreiber, S.L. | 登録日 | 1995-11-09 | 公開日 | 1996-03-08 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc.Natl.Acad.Sci.USA, 92, 1995
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2PE0
| CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE, GLYCEROL, ... | 著者 | Whitlow, M, Adler, M. | 登録日 | 2007-04-01 | 公開日 | 2007-06-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity. Bioorg.Med.Chem.Lett., 17, 2007
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