1RHZ
| The structure of a protein conducting channel | 分子名称: | Preprotein translocase secE subunit, Preprotein translocase secY subunit, SecBeta | 著者 | van den Berg, B, Clemons Jr, W.M, Collinson, I, Modis, Y, Hartmann, E, Harrison, S.C, Rapoport, T.A. | 登録日 | 2003-11-15 | 公開日 | 2004-01-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | X-ray structure of a protein-conducting channel. Nature, 427, 2004
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4MHA
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817 | 分子名称: | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Zhang, W, Mciver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, D.B.M, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, Dipaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
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4M3Q
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | 著者 | Zhang, W, Zhang, D, Stashko, M.A, DeRyckere, D, Hunter, D, Kireev, D.B, Miley, M, Cummings, C, Lee, M, Norris-Drouin, J, Stewart, W.M, Sather, S, Zhou, Y, Kirkpatrick, G, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-06 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.718 Å) | 主引用文献 | Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors. J.Med.Chem., 56, 2013
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4MH7
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-methylpyrimidine-5-carboxamide, ... | 著者 | Zhang, W, McIver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, M.J, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, DiPaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
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4ORD
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6OVU
| Coiled-coil Trimer with Glu:3,4-difluorophenylalanine:Lys Triad | 分子名称: | Coiled-coil Trimer with Glu:3,4-difluorophenylalanine:Lys Triad | 著者 | Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. | 登録日 | 2019-05-08 | 公開日 | 2020-04-29 | 最終更新日 | 2020-05-20 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle. Biochemistry, 59, 2020
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6OFD
| The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P, Kan, M.W. | 登録日 | 2019-03-29 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182, 2019
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6OV9
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6OVS
| Coiled-coil Trimer with Glu:Tyr:Lys Triad | 分子名称: | Coiled-coil Trimer with Glu:Tyr:Lys Triad, PENTAETHYLENE GLYCOL | 著者 | Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. | 登録日 | 2019-05-08 | 公開日 | 2020-04-29 | 最終更新日 | 2020-05-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle. Biochemistry, 59, 2020
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6OVV
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6OSD
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2KZH
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6OF5
| The crystal structure of dodecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... | 著者 | Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P. | 登録日 | 2019-03-28 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182, 2019
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6OS8
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3IK5
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3IK9
| Human GST A1-1-GIMF with GSDHN | 分子名称: | (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, Glutathione S-transferase A1 | 著者 | Balogh, L.M, Le Trong, I, Atkins, W.M, Stenkamp, R.E. | 登録日 | 2009-08-05 | 公開日 | 2010-06-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry, 49, 2010
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3IK7
| Human glutathione transferase a4-4 with GSDHN | 分子名称: | (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, Glutathione S-transferase A4, SULFATE ION | 著者 | Balogh, L.M, Le Trong, I, Atkins, W.M, Stenkamp, R.E. | 登録日 | 2009-08-05 | 公開日 | 2010-06-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry, 49, 2010
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3IOZ
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4ITX
| P113S mutant of E. coli Cystathionine beta-lyase MetC inhibited by reaction with L-Ala-P | 分子名称: | CALCIUM ION, Cystathionine beta-lyase MetC, {1-[(3-HYDROXY-METHYL-5-PHOSPHONOOXY-METHYL-PYRIDIN-4-YLMETHYL)-AMINO]-ETHYL}-PHOSPHONIC ACID | 著者 | Squire, C.J, Yosaatmadja, Y, Soo, V.W.C, Patrick, W.M. | 登録日 | 2013-01-19 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
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8UOZ
| EmrE structure in the TPP-bound state (WT/E14Q heterodimer) | 分子名称: | SMR family multidrug efflux protein EmrE, TETRAPHENYLPHOSPHONIUM | 著者 | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | 登録日 | 2023-10-20 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | SOLID-STATE NMR, SOLUTION NMR | 主引用文献 | Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE. Nat Commun, 15, 2024
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8UWU
| EmrE structure in the proton-bound state (WT/L51I heterodimer) | 分子名称: | SMR family multidrug efflux protein EmrE | 著者 | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | 登録日 | 2023-11-08 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | SOLID-STATE NMR, SOLUTION NMR | 主引用文献 | Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE. Nat Commun, 15, 2024
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3I6A
| Human GST A1-1 GIMF mutant with Glutathione | 分子名称: | GLUTATHIONE, Glutathione S-transferase A1 | 著者 | Balogh, L.M, Le Trong, I, Stenkamp, R.E, Atkins, W.M. | 登録日 | 2009-07-06 | 公開日 | 2009-09-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry, 48, 2009
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4GTN
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4JO6
| Streptavidin complex with SBP-Tag | 分子名称: | SBP-Tag, Streptavidin | 著者 | Barrette-Ng, I.H, Wu, S.C, Tjia, W.M, Wong, S.L, Ng, K.K.S. | 登録日 | 2013-03-17 | 公開日 | 2013-05-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits Acta Crystallogr.,Sect.D, 69, 2013
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3I69
| Apo Glutathione Transferase A1-1 GIMF-helix mutant | 分子名称: | GLUTATHIONE, Glutathione S-transferase A1 | 著者 | Balogh, L.M, Le Trong, I, Stenkamp, R.E, Atkins, W.M. | 登録日 | 2009-07-06 | 公開日 | 2009-09-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry, 48, 2009
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