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3DCC
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BU of 3dcc by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
分子名称: 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
著者Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3D8W
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BU of 3d8w by Molmil
Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
分子名称: 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase II, ZINC ION
著者Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
登録日2008-05-26
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DBU
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BU of 3dbu by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
分子名称: 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
著者Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
登録日2008-06-02
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DD0
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BU of 3dd0 by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
分子名称: 6-ethoxy-1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
著者Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DVC
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BU of 3dvc by Molmil
X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Avvaru, B.S.
登録日2008-07-18
公開日2008-11-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008
3DC3
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BU of 3dc3 by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION
著者Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DC9
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BU of 3dc9 by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
分子名称: Carbonic anhydrase 2, ZINC ION
著者Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DV7
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BU of 3dv7 by Molmil
Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A)
分子名称: Carbonic anhydrase 2, ZINC ION
著者Avvaru, B.S.
登録日2008-07-18
公開日2008-11-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008
3DVD
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BU of 3dvd by Molmil
X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Avvaru, B.S.
登録日2008-07-18
公開日2008-11-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008
3DVB
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BU of 3dvb by Molmil
X-ray crystal structure of mutant N62V human Carbonic Anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Avvaru, B.S.
登録日2008-07-18
公開日2008-11-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008
3RG3
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BU of 3rg3 by Molmil
Crystal structure of the W5E mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Domsic, J.F, Robbins, A.H, McKenna, R.
登録日2011-04-07
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
Arch.Biochem.Biophys., 516, 2011
3RLD
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BU of 3rld by Molmil
Crystal structure of the Y7I mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, SULFATE ION, ZINC ION
著者Avvaru, B.S, Mikulski, R, McKenna, R.
登録日2011-04-19
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II.
Arch.Biochem.Biophys., 506, 2011
3RG4
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BU of 3rg4 by Molmil
Crystal structure of the W5F mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Domsic, J.F, Robbins, A.H, McKenna, R.
登録日2011-04-07
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
Arch.Biochem.Biophys., 516, 2011
3RGE
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BU of 3rge by Molmil
Crystal structure of the W5H mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Domsic, J.F, Robbins, A.H, McKenna, R.
登録日2011-04-08
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
Arch.Biochem.Biophys., 516, 2011
3KKX
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BU of 3kkx by Molmil
Neutron structure of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Fisher, S.Z, Langan, P.A.
登録日2009-11-06
公開日2010-01-12
最終更新日2023-09-06
実験手法NEUTRON DIFFRACTION (2 Å)
主引用文献Neutron structure of human carbonic anhydrase II: implications for proton transfer.
Biochemistry, 49, 2010
3KOK
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BU of 3kok by Molmil
Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5
分子名称: COBALT (II) ION, Carbonic anhydrase 2
著者Avvaru, B.S.
登録日2009-11-13
公開日2010-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Arch.Biochem.Biophys., 502, 2010
3MNK
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BU of 3mnk by Molmil
Human Carbonic Anhydrase II Mutant K170H
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3KOI
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BU of 3koi by Molmil
Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0
分子名称: COBALT (III) ION, Carbonic anhydrase 2
著者Avvaru, B.S.
登録日2009-11-13
公開日2010-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Arch.Biochem.Biophys., 502, 2010
3KON
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BU of 3kon by Molmil
Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0
分子名称: COBALT (II) ION, Carbonic anhydrase 2
著者Avvaru, B.S.
登録日2009-11-13
公開日2010-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Arch.Biochem.Biophys., 502, 2010
3KS3
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BU of 3ks3 by Molmil
High resolution structure of Human Carbonic Anhydrase II at 0.9 A
分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION
著者Avvaru, B.S.
登録日2009-11-20
公開日2010-01-26
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献A short, strong hydrogen bond in the active site of human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNH
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BU of 3mnh by Molmil
Human Carbonic Anhydrase II Mutant K170A
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNI
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BU of 3mni by Molmil
Human Carbonic Anhydrase II Mutant K170D
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNJ
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BU of 3mnj by Molmil
Human Carbonic Anhydrase II Mutant K170E
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
4FIK
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BU of 4fik by Molmil
Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products
分子名称: 2,4-dihydroxybenzenesulfenic acid, 4,4'-disulfanediyldibenzene-1,3-diol, 4-MERCAPTOBENZENE-1,3-DIOL, ...
著者Sippel, K.H, Genis, C, Govindasamy, L, Agbandje-McKenna, M, Tripp, B.C, McKenna, R.
登録日2012-06-08
公開日2012-06-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
J Phys Chem Lett, 1, 2010
3CAJ
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BU of 3caj by Molmil
Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
分子名称: 6-ethoxy-1,3-benzothiazole-2-sulfonamide, CHLORIDE ION, Carbonic anhydrase 2, ...
著者Di Fiore, A, De Simone, G.
登録日2008-02-20
公開日2008-04-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Bioorg.Med.Chem.Lett., 18, 2008

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