6TWA
 
 | | Human CD73 (ecto 5'-nucleotidase) in complex with PSB12646 (an AOPCP derivative, compound 20 in publication) in the closed state | | 分子名称: | 5'-nucleotidase, CALCIUM ION, ZINC ION, ... | | 著者 | Pippel, J, Strater, N. | | 登録日 | 2020-01-12 | | 公開日 | 2020-02-19 | | 最終更新日 | 2020-04-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.
J.Med.Chem., 63, 2020
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6TWF
 | | Human CD73 (ecto 5'-nucleotidase) in complex with PSB12604 (an AOPCP derivative, compound 21 in publication) in the closed state | | 分子名称: | 5'-nucleotidase, CALCIUM ION, ZINC ION, ... | | 著者 | Pippel, J, Strater, N. | | 登録日 | 2020-01-13 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.
J.Med.Chem., 63, 2020
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6TW0
 | | Human CD73 (ecto 5'-nucleotidase) in complex with PSB12690 (an AOPCP derivative, compound 10 in publication) in the closed state | | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | | 著者 | Pippel, J, Strater, N. | | 登録日 | 2020-01-10 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.
J.Med.Chem., 63, 2020
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6TVX
 | | Human CD73 (ecto 5'-nucleotidase) in complex with PSB12676 (an AOPCP derivative, compound 9 in paper) in the closed state | | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | | 著者 | Pippel, J, Strater, N. | | 登録日 | 2020-01-10 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.
J.Med.Chem., 63, 2020
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3O5B
 | | Crystal structure of dimeric KlHxk1 in crystal form VII with glucose bound (open state) | | 分子名称: | Hexokinase, SULFATE ION, beta-D-glucopyranose | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-28 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3CJ9
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3O08
 | | Crystal structure of dimeric KlHxk1 in crystal form I | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hexokinase, SULFATE ION | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-19 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3O4W
 | | Crystal structure of dimeric KlHxk1 in crystal form IV | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Hexokinase, ... | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-27 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3O8M
 | | Crystal structure of monomeric KlHxk1 in crystal form XI with glucose bound (closed state) | | 分子名称: | CHLORIDE ION, Hexokinase, alpha-D-glucopyranose, ... | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-08-03 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3CJ7
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3CJ1
 | | Structure of Rattus norvegicus NTPDase2 | | 分子名称: | Ectonucleoside triphosphate diphosphohydrolase 2 | | 著者 | Zebisch, M, Strater, N. | | 登録日 | 2008-03-12 | | 公開日 | 2008-04-29 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3CJA
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3O1B
 | | CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM II | | 分子名称: | Hexokinase | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-21 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3O1W
 | | Crystal structure of dimeric KlHxk1 in crystal form III | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Hexokinase, ... | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-22 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3O6W
 | | Crystal structure of monomeric KlHxk1 in crystal form VIII (open state) | | 分子名称: | GLYCEROL, Hexokinase, PHOSPHATE ION | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-29 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3O80
 | | Crystal structure of monomeric KlHxk1 in crystal form IX (open state) | | 分子名称: | Hexokinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-08-02 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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4A5B
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4OKF
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4O36
 | | Semisynthetic RNase S1-15-H7/11-Q10 | | 分子名称: | CHLORIDE ION, Ribonuclease pancreatic, S-peptide, ... | | 著者 | Genz, M, Strater, N. | | 登録日 | 2013-12-18 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | An Artificial Imine Reductase based on the Ribonuclease S scaffold
Chem.Cat.Chem, 2014
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4O37
 | | seminsynthetic RNase S1-15-3Pl-7/11 | | 分子名称: | CHLORIDE ION, Ribonuclease pancreatic, S-peptide, ... | | 著者 | Genz, M, Strater, N. | | 登録日 | 2013-12-18 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | An Artificial Imine Reductase based on the Ribonuclease S Scaffold
Chem.Cat.Chem, 2014
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4JAX
 | | Crystal structure of dimeric KlHxk1 in crystal form X | | 分子名称: | GLYCEROL, Hexokinase, PHOSPHATE ION | | 著者 | Kuettner, E.B, Strater, N, Kettner, K, Otto, A, Lilie, H, Golbik, R.P, Kriegel, T.M. | | 登録日 | 2013-02-19 | | 公開日 | 2013-05-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1.
Biochem.Biophys.Res.Commun., 435, 2013
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4JEP
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4KH5
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4KH4
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4KH6
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