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Trypanosoma brucei PTR1 in complex with inhibitor 4c (F188)
分子名称:	2-amino-1,3-benzothiazole-6-carboxamide, ACETATE ION, GLYCEROL, ...
著者	Landi, G, Pozzi, C, Mangani, S.
登録日	2018-04-21
公開日	2019-04-03
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J.Med.Chem., 62, 2019

Ternary complex between E. coli thymidylate synthase, dUMP, and F9
分子名称:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-oxo-2H-naphtho[1,8-bc]furan-6-yl 4-nitrobenzoate, SULFATE ION, ...
著者	Mangani, S, Pozzi, C, Ferrari, S, Costi, M.P.
登録日	2013-07-20
公開日	2013-11-06
最終更新日	2013-12-11
実験手法	X-RAY DIFFRACTION (2.41 Å)
主引用文献	2'-Deoxyuridine 5'-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives. J.Med.Chem., 56, 2013

Trypanosoma brucei PTR1 in complex with inhibitor WHF30
分子名称:	3-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-THIOPHEN-2-YLPROPAN-1-ONE, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者	Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P.
登録日	2011-05-06
公開日	2012-05-23
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.01 Å)
主引用文献	Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017

Trypanosoma brucei PTR1 in complex with inhibitor WH16
分子名称:	(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
著者	Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P.
登録日	2011-05-03
公開日	2012-05-23
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017