6IO0
| Human IDH1 R132C mutant complexed with compound A. | 分子名称: | (2E)-3-{3-[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbonyl]-1-methyl-1H-indol-7-yl}prop-2-enoic acid, CITRIC ACID, GLYCEROL, ... | 著者 | Suzuki, M, Baba, D, Hanzawa, H. | 登録日 | 2018-10-29 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model. Mol.Cancer Ther., 19, 2020
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3W5E
| Crystal structure of phosphodiesterase 4B in complex with compound 31e | 分子名称: | CALCIUM ION, N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide, ZINC ION, ... | 著者 | Takahashi, M, Hanzawa, H. | 登録日 | 2013-01-28 | 公開日 | 2013-05-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors Bioorg.Med.Chem.Lett., 23, 2013
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3WD9
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