8CNI
 
 | | PHT1 in the outward facing conformation, bound to Sb27 | | 分子名称: | Solute carrier family 15 member 4, Sybody 27 | | 著者 | Custodio, T, Killer, M, Loew, C. | | 登録日 | 2023-02-23 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.
Nat Commun, 14, 2023
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7A25
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8R8Q
 | | Lysosomal peptide transporter | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosylated lysosomal membrane protein, Major facilitator superfamily domain-containing protein 1 | | 著者 | Jungnickel, K.E.J, Loew, C. | | 登録日 | 2023-11-29 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.08 Å) | | 主引用文献 | MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes.
Nat.Cell Biol., 2024
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7OXK
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7OXJ
 | | ttSlyD with M8A pseudo-wild-type S2 peptide | | 分子名称: | 30S ribosomal protein S2, CHLORIDE ION, Fragment of 30S ribosomal protein S2 peptide, ... | | 著者 | Pazicky, S, Lei, J, Loew, C. | | 登録日 | 2021-06-22 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
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7OXH
 | | ttSlyD with pseudo-wild-type S2 peptide | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 30S ribosomal protein S2, CHLORIDE ION, ... | | 著者 | Pazicky, S, Lei, J, Loew, C. | | 登録日 | 2021-06-22 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
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7OXI
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7OXG
 | | ttSlyD FKBP domain with M8A pseudo-wild-type S2 peptide | | 分子名称: | 30S ribosomal protein S2, CHLORIDE ION, IMIDAZOLE, ... | | 著者 | Pazicky, S, Lei, J, Loew, C. | | 登録日 | 2021-06-22 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
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6ZN3
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6EIA
 | | PepTSt in complex with HEPES (100 mM) | | 分子名称: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Martinez Molledo, M, Quistgaard, E.M, Loew, C. | | 登録日 | 2017-09-18 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
Structure, 26, 2018
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7PMX
 | | HsPepT1 bound to Ala-Phe in the outward facing open conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PMY
 | | HsPepT2 bound to Ala-Phe in the inward facing partially occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 2 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-04 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PMW
 | | HsPepT1 bound to Ala-Phe in the outward facing occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PN1
 | | Apo HsPepT1 in the outward facing open conformation | | 分子名称: | Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-04 | | 公開日 | 2021-10-20 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7A29
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8AFO
 | | Structure of fibronectin 2 and 3 of L1CAM at 2.0 Angstrom | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neural cell adhesion molecule L1 | | 著者 | Guedez, G, Loew, C. | | 登録日 | 2022-07-18 | | 公開日 | 2023-03-08 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | X-ray structure and function of fibronectin domains two and three of the neural cell adhesion molecule L1.
Faseb J., 37, 2023
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8B17
 | | DtpB-Nb132-AWA | | 分子名称: | ALA-TRP-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1D
 | | DtpB-Nb132-APF | | 分子名称: | ALA-PRO-PHE, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1B
 | | DtpB-Nb132-AL | | 分子名称: | ALA-LEU, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B19
 | | DtpB-Nb132-AFA | | 分子名称: | ALA-PHE-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1I
 | | DtpB-Nb132-MS | | 分子名称: | DECANE, DODECANE, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1K
 | | DtpB-Nb132-NV | | 分子名称: | ASN-VAL, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1J
 | | DtpB-Nb132-SL | | 分子名称: | DECANE, DODECANE, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1C
 | | DtpB-Nb132-ALA | | 分子名称: | ALA-LEU-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B18
 | | DtpB-Nb132-AF | | 分子名称: | ALA-PHE, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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