4ODK
 
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4ODR
 | | Structure of SlyD delta-IF from Thermus thermophilus in complex with FK506 | | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ACETATE ION, CHLORIDE ION, ... | | 著者 | Quistgaard, E.M, Low, C, Nordlund, P. | | 登録日 | 2014-01-10 | | 公開日 | 2015-01-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.929 Å) | | 主引用文献 | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
BMC Biol., 14, 2016
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4JA3
 | | Partially occluded inward open conformation of the xylose transporter XylE from E. coli | | 分子名称: | CADMIUM ION, D-xylose-proton symporter, LUTETIUM (III) ION | | 著者 | Quistgaard, E.M, Low, C, Moberg, P, Tresaugues, L, Nordlund, P. | | 登録日 | 2013-02-18 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Nat.Struct.Mol.Biol., 20, 2013
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4JA4
 | | Inward open conformation of the xylose transporter XylE from E. coli | | 分子名称: | CADMIUM ION, D-xylose-proton symporter | | 著者 | Quistgaard, E.M, Low, C, Moberg, P, Tresaugues, L, Nordlund, P. | | 登録日 | 2013-02-18 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Nat.Struct.Mol.Biol., 20, 2013
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8CGC
 | | Structure of CSF1R in complex with a pyrollopyrimidine (compound 23) | | 分子名称: | (2S)-2-hydroxybutanedioic acid, GLYCEROL, Macrophage colony-stimulating factor 1 receptor, ... | | 著者 | Aarhus, T.I, Bjornstad, F, Wolowczyk, C, Larsen, K.U, Rognstad, L, Leithaug, T, Unger, A, Habenberger, P, Wolff, A, Bjorkoy, G, Pridans, C, Eickhoff, J, Klebl, B, Hoff, B.H, Sundby, E. | | 登録日 | 2023-02-03 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.925 Å) | | 主引用文献 | Synthesis and Development of Highly Selective Pyrrolo[2,3- d ]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
J.Med.Chem., 66, 2023
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5MHQ
 | | CCT068127 in complex with CDK2 | | 分子名称: | (2~{R},3~{S})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol, Cyclin-dependent kinase 2 | | 著者 | Whittaker, S.R, Barlow, C, Martin, M.P, Mancusi, C, Wagner, S, Barrie, E, te Poele, R, Sharp, S, Brown, N, Wilson, S, Clarke, P, Walton, M.I, MacDonald, E, Blagg, J, Noble, M.E.M, Garrett, M.D, Workman, P. | | 登録日 | 2016-11-25 | | 公開日 | 2017-12-20 | | 最終更新日 | 2018-03-14 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Mol Oncol, 12, 2018
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1N03
 | | Model for Active RecA Filament | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RecA protein | | 著者 | VanLoock, M.S, Yu, X, Yang, S, Lai, A.L, Low, C, Campbell, M.J, Egelman, E.H. | | 登録日 | 2002-10-10 | | 公開日 | 2003-02-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (20 Å) | | 主引用文献 | ATP-Mediated Conformational Changes in the RecA Filament
Structure, 11, 2003
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6V1V
 | | VIP3B (VIP3B_2160) adapted for crystallization | | 分子名称: | Vegetative insecticidal protein | | 著者 | Evdokimov, A.G, Zheng, M, Moshiri, F, Haas, J, Lowder, C. | | 登録日 | 2019-11-21 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.189 Å) | | 主引用文献 | Crystal structure of a Vip3B family insecticidal protein reveals a new fold and a unique tetrameric assembly.
Protein Sci., 29, 2020
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3KVS
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2BPQ
 | | Anthranilate phosphoribosyltransferase (TrpD) from Mycobacterium tuberculosis (Apo structure) | | 分子名称: | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, BENZAMIDINE, GLYCEROL | | 著者 | Lee, C.E, Goodfellow, C, Javid-Majd, F, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2005-04-22 | | 公開日 | 2006-01-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Crystal Structure of Trpd, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium Tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate
J.Mol.Biol., 355, 2006
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1ZVW
 | | The Crystal Structure of TrpD (Rv2192c) from Mycobacterium tuberculosis in Complex with PRPP and Magnesium | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, BENZAMIDINE, ... | | 著者 | Lee, C.E, Lott, J.S, Baker, E.N, Arcus, V.L, Javid-Majd, F, Goodfellow, C, Hung, L.-W, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2005-06-02 | | 公開日 | 2006-01-17 | | 最終更新日 | 2021-08-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate.
J.Mol.Biol., 355, 2006
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4NY3
 | | Human PTPA in complex with peptide | | 分子名称: | GLYCEROL, SULFATE ION, Serine/threonine-protein phosphatase 2A activator, ... | | 著者 | Loew, C, Quistgaard, E.M, Nordlund, P. | | 登録日 | 2013-12-10 | | 公開日 | 2014-07-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | | 主引用文献 | Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Biol.Chem., 395, 2014
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2RND
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2RMY
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7PMY
 | | HsPepT2 bound to Ala-Phe in the inward facing partially occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 2 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-04 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PN1
 | | Apo HsPepT1 in the outward facing open conformation | | 分子名称: | Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-04 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PMW
 | | HsPepT1 bound to Ala-Phe in the outward facing occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7PMX
 | | HsPepT1 bound to Ala-Phe in the outward facing open conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
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7A25
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7ZC2
 | | Dipeptide and tripeptide Permease C (DtpC) | | 分子名称: | Amino acid/peptide transporter | | 著者 | Killer, M, Finocchio, G, Pardon, E, Steyaert, J, Loew, C. | | 登録日 | 2022-03-25 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Front Mol Biosci, 9, 2022
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8R8Q
 | | Lysosomal peptide transporter | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosylated lysosomal membrane protein, Major facilitator superfamily domain-containing protein 1 | | 著者 | Jungnickel, K.E.J, Loew, C. | | 登録日 | 2023-11-29 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (4.08 Å) | | 主引用文献 | MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes.
Nat.Cell Biol., 26, 2024
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8CNI
 | | PHT1 in the outward facing conformation, bound to Sb27 | | 分子名称: | Solute carrier family 15 member 4, Sybody 27 | | 著者 | Custodio, T, Killer, M, Loew, C. | | 登録日 | 2023-02-23 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.
Nat Commun, 14, 2023
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7A29
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6ZN3
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7OXI
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