8ADB
 
 | | Viral tegument-like DUBs | | 分子名称: | CITRIC ACID, Polyubiquitin-C, Wc-VDT1, ... | | 著者 | Erven, I, Abraham, E.T, Hermanns, T, Baumann, U, Hofmann, K. | | 登録日 | 2022-07-08 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.
Nat Commun, 13, 2022
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8ADC
 | | Viral tegument-like DUBs | | 分子名称: | Viral deubiquitinating enzyme | | 著者 | Erven, I, Abraham, E.T, Hermanns, T, Baumann, U, Hofmann, K. | | 登録日 | 2022-07-08 | | 公開日 | 2023-02-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.
Nat Commun, 13, 2022
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8CMR
 | | Linear specific OTU-type DUB SnOTU from the pathogen S. negenvensis in complex with linear di-ubiquitin | | 分子名称: | OTU domain-containing protein, Polyubiquitin-B | | 著者 | Uthoff, M, Hermanns, T, Boll, V, Hofmann, K, Baumann, U. | | 登録日 | 2023-02-21 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Functional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis.
Nat Commun, 14, 2023
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4PHY
 | | Functional conservation despite structural divergence in ligand-responsive RNA switches | | 分子名称: | ACETATE ION, MAGNESIUM ION, RNA (26-MER), ... | | 著者 | Boerneke, M.A, Dibrov, S.M, Hermann, T.H. | | 登録日 | 2014-05-07 | | 公開日 | 2015-02-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Functional conservation despite structural divergence in ligand-responsive RNA switches.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4P97
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3LOA
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3BR9
 | | Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor | | 分子名称: | (2R)-2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)propanamide, RNA-directed RNA polymerase | | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | | 登録日 | 2007-12-21 | | 公開日 | 2008-12-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Bioorg.Med.Chem.Lett., 18, 2008
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3BSC
 | | Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor | | 分子名称: | 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one, RNA-directed RNA polymerase | | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | | 登録日 | 2007-12-23 | | 公開日 | 2008-12-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Bioorg.Med.Chem.Lett., 18, 2008
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3BSA
 | | Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor | | 分子名称: | 2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(1,3-thiazol-5-yl)-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase | | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | | 登録日 | 2007-12-23 | | 公開日 | 2008-12-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Bioorg.Med.Chem.Lett., 18, 2008
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2NOK
 | | Crystal Structure of an RNA domain from Hepatitis C virus. | | 分子名称: | 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3', 5'-R(*GP*CP*GP*UP*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*UP*CP*CP*GP*G)-3', MAGNESIUM ION, ... | | 著者 | Dibrov, S.M, Johnston-Cos, H, Weng, Y.H. | | 登録日 | 2006-10-25 | | 公開日 | 2007-02-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution.
Angew.Chem.Int.Ed.Engl., 46, 2007
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2PN4
 | | Crystal Structure of Hepatitis C Virus IRES Subdomain IIa | | 分子名称: | 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3', 5'-R(*GP*CP*GP*(5BU)P*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*(5BU)P*CP*CP*GP*G)-3', STRONTIUM ION | | 著者 | Zhao, Q, Han, Q, Kissinger, C.R, Thompson, P.A. | | 登録日 | 2007-04-23 | | 公開日 | 2008-04-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structure of hepatitis C virus IRES subdomain IIa.
Acta Crystallogr.,Sect.D, 64, 2008
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5N12
 | | Crystal structure of TCE treated rPPEP-1 | | 分子名称: | 2,2,2-tris-chloroethanol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ... | | 著者 | Pichlo, C, Schacherl, M, Baumann, U. | | 登録日 | 2017-02-04 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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6FSM
 | | Crystal structure of TCE-treated Thermolysin | | 分子名称: | CALCIUM ION, GLYCEROL, LYSINE, ... | | 著者 | Pichlo, C, Baumann, U. | | 登録日 | 2018-02-19 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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6FSJ
 | | Crystal structure of TCE-treated Lysozyme | | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, Lysozyme C | | 著者 | Pichlo, C, Baumann, U. | | 登録日 | 2018-02-19 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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