2BIM
 
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2BIN
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2BIO
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2BIP
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1YPC
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1YPB
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1YPA
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1ZT4
 | | The crystal structure of human CD1d with and without alpha-Galactosylceramide | | 分子名称: | Beta-2-microglobulin, N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE, T-cell surface glycoprotein CD1d | | 著者 | Koch, M, Stronge, V.S, Shepherd, D, Gadola, S.D, Mathew, B, Ritter, G, Fersht, A.R, Besra, G.S, Schmidt, R.R, Jones, E.Y, Cerundolo, V, Structural Proteomics in Europe (SPINE) | | 登録日 | 2005-05-26 | | 公開日 | 2005-07-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The crystal structure of human CD1d with and without alpha-galactosylceramide
Nat.Immunol., 6, 2005
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1ZTR
 | | Solution structure of Engrailed homeodomain L16A mutant | | 分子名称: | Segmentation polarity homeobox protein engrailed | | 著者 | Religa, T.L, Markson, J.S, Mayor, U, Freund, S.M.V, Fersht, A.R. | | 登録日 | 2005-05-27 | | 公開日 | 2005-10-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a protein denatured state and folding intermediate.
Nature, 437, 2005
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1UOL
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2L9V
 | | NMR structure of the FF domain L24A mutant's folding transition state | | 分子名称: | Pre-mRNA-processing factor 40 homolog A | | 著者 | Korzhnev, D.M, Vernon, R.M, Religa, T.L, Hansen, A, Baker, D, Fersht, A.R, Kay, L.E. | | 登録日 | 2011-02-24 | | 公開日 | 2011-09-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study.
J.Am.Chem.Soc., 133, 2011
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2NNT
 | | General structural motifs of amyloid protofilaments | | 分子名称: | Transcription elongation regulator 1 | | 著者 | Ferguson, N, Becker, J, Tidow, H, Tremmel, S, Sharpe, T.D, Krause, G, Flinders, J, Petrovich, M, Berriman, J, Oschkinat, H, Fersht, A.R. | | 登録日 | 2006-10-24 | | 公開日 | 2006-11-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | General structural motifs of amyloid protofilaments.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2C6A
 | | Solution structure of the C4 zinc-finger domain of HDM2 | | 分子名称: | UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION | | 著者 | Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. | | 登録日 | 2005-11-08 | | 公開日 | 2006-01-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15, 2006
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2C6B
 | | Solution structure of the C4 zinc-finger domain of HDM2 | | 分子名称: | UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION | | 著者 | Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. | | 登録日 | 2005-11-08 | | 公開日 | 2006-01-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15, 2006
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5AOJ
 | | Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid | | 分子名称: | 2-hydroxy-3,5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Joerger, A.C, Baud, M.G, Bauer, M.R, Fersht, A.R. | | 登録日 | 2015-09-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.
Structure, 23, 2015
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2FEJ
 | | Solution structure of human p53 DNA binding domain. | | 分子名称: | Cellular tumor antigen p53, ZINC ION | | 著者 | Perez-Canadillas, J.M, Tidow, H, Freund, S.M, Rutherford, T.J, Ang, H.C, Fersht, A.R. | | 登録日 | 2005-12-16 | | 公開日 | 2006-01-31 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of p53 core domain: Structural basis for its instability
Proc.Natl.Acad.Sci.Usa, 103, 2006
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5NP0
 | | Closed dimer of human ATM (Ataxia telangiectasia mutated) | | 分子名称: | Serine-protein kinase ATM | | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | | 登録日 | 2017-04-13 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
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5NP1
 | | Open protomer of human ATM (Ataxia telangiectasia mutated) | | 分子名称: | Serine-protein kinase ATM | | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | | 登録日 | 2017-04-13 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
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5O1D
 | | p53 cancer mutant Y220C in complex with compound MB481 | | 分子名称: | 3-iodanyl-2-oxidanyl-5-propoxy-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1C
 | | p53 cancer mutant Y220C in complex with compound MB184 | | 分子名称: | 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, ZINC ION | | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1I
 | | p53 cancer mutant Y220C in complex with compound MB710 | | 分子名称: | 1,2-ETHANEDIOL, 2-(diethylamino)-6-iodanyl-5-oxidanyl-7-pyrrol-1-yl-1,3-benzothiazole-4-carboxylic acid, Cellular tumor antigen p53, ... | | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1F
 | | p53 cancer mutant Y220C in complex with compound MB582 | | 分子名称: | 5-butoxy-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, ZINC ION | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1E
 | | p53 cancer mutant Y220C im complex with compound MB577 | | 分子名称: | 3-iodanyl-2-oxidanyl-5-prop-2-enoxy-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1A
 | | p53 cancer mutant Y220C in complex with compound MB240 | | 分子名称: | Cellular tumor antigen p53, GLYCEROL, ZINC ION, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1H
 | | p53 cancer mutant Y220C in complex with compound MB539 | | 分子名称: | 3-iodanyl-2-oxidanyl-5-propylsulfanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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