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Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors
分子名称:	BETA-SECRETASE 1, N-(6-chloro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-3-[2-propyl-4-(1H-pyrazol-4-yl)thiophen-3-yl]-L-alanine, ZINC ION
著者	Lougheed, J.C, Brecht, E, Yao, N.H.
登録日	2012-11-20
公開日	2013-03-06
最終更新日	2024-10-30
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013

Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
分子名称:	3-[2-bromo-4-(1H-pyrazol-4-yl)thiophen-3-yl]-N-(6-chloro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-alanine, Beta-secretase 1, ZINC ION
著者	Yao, N, Brecht, E.
登録日	2012-11-16
公開日	2013-03-06
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013

Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
分子名称:	Beta-secretase 1, N-(6-chloro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-3-[4-(1H-pyrazol-4-yl)thiophen-3-yl]-L-alanine, ZINC ION
著者	Yao, N, Brecht, E.
登録日	2012-11-16
公開日	2013-03-06
最終更新日	2013-07-03
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013

SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
分子名称:	Beta-secretase 1, N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({1-[4-(2,2-dimethylpropyl)thiophen-2-yl]cyclopropyl}amino)-2-hydroxypropyl]acetamide
著者	Yao, N, Brecht, E.
登録日	2012-11-16
公開日	2013-11-20
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors To be Published