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6U6W
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Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
分子名称: 5-bromo-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5
著者Zhao, B, Wang, F.
登録日2019-08-30
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
6K9P
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Structure of Deubiquitinase
分子名称: Ubiquitin, Ubiquitin thioesterase
著者Lu, L.N, Liu, L, Wang, F.
登録日2019-06-17
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.047 Å)
主引用文献Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains
Nat Commun, 13, 2022
6U8O
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Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
分子名称: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5
著者Zhao, B, Wang, F.
登録日2019-09-05
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
6U8L
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BU of 6u8l by Molmil
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
分子名称: 3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid, N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amine, WD repeat-containing protein 5
著者Zhao, B, Wang, F.
登録日2019-09-05
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
4KN8
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BU of 4kn8 by Molmil
Crystal structure of Bs-TpNPPase
分子名称: Thermostable NPPase
著者Guo, Z, Wang, F, Huang, J, Gong, W, Ji, C.
登録日2013-05-09
公開日2014-04-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.502 Å)
主引用文献Crystal Structure of Thermostable p-nitrophenylphosphatase from Bacillus Stearothermophilus (Bs-TpNPPase)
PROTEIN PEPT.LETT., 21, 2014
1T3P
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BU of 1t3p by Molmil
Half-sandwich arene ruthenium(II)-enzyme complex
分子名称: ACETATE ION, CHLORIDE ION, Lysozyme C, ...
著者McNae, I.W, Fishburne, K, Habtemariam, A, Hunter, T.M, Melchart, M, Wang, F, Walkinshaw, M.D, Sadler, P.J.
登録日2004-04-27
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Half-sandwich arene ruthenium(II)-enzyme complex
CHEM.COMMUN.(CAMB.), 16, 2004
3TLQ
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BU of 3tlq by Molmil
Crystal structure of EAL-like domain protein YdiV
分子名称: GLYCEROL, PHOSPHATE ION, Regulatory protein YdiV
著者Li, B, Li, N, Wang, F, Guo, L, Liu, C, Zhu, D, Xu, S, Gu, L.
登録日2011-08-30
公開日2012-09-12
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility
Nucleic Acids Res., 40, 2012
7L5W
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BU of 7l5w by Molmil
p97-R155H mutant dodecamer I
分子名称: Transitional endoplasmic reticulum ATPase
著者Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
登録日2020-12-23
公開日2021-08-04
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7L5X
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p97-R155H mutant dodecamer II
分子名称: Transitional endoplasmic reticulum ATPase
著者Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
登録日2020-12-23
公開日2021-08-04
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7JRJ
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BU of 7jrj by Molmil
Chlamydomonas reinhardtii radial spoke head and neck (recombinant)
分子名称: Flagellar radial spoke protein 1, Flagellar radial spoke protein 10, Flagellar radial spoke protein 2, ...
著者Grossman-Haham, I, Coudray, N, Yu, Z, Wang, F, Zhang, N, Bhabha, G, Vale, R.D.
登録日2020-08-12
公開日2020-12-16
最終更新日2021-01-27
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating.
Nat.Struct.Mol.Biol., 28, 2021
7R7S
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p47-bound p97-R155H mutant with ATPgammaS
分子名称: NSFL1 cofactor p47, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
著者Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
登録日2021-06-25
公開日2021-08-04
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.23 Å)
主引用文献Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7R7T
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BU of 7r7t by Molmil
p47-bound p97-R155H mutant with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase
著者Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
登録日2021-06-25
公開日2021-08-04
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7R7U
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BU of 7r7u by Molmil
D1 and D2 domain structure of the p97(R155H)-p47 complex
分子名称: Transitional endoplasmic reticulum ATPase
著者Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
登録日2021-06-25
公開日2021-08-04
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
6IIK
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BU of 6iik by Molmil
USP14 catalytic domain with IU1
分子名称: 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14
著者Mei, Z.Q, Wang, Y.W, He, W, Wang, F.
登録日2018-10-06
公開日2018-12-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade.
Cell Res., 28, 2018
3QRG
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BU of 3qrg by Molmil
Crystal structure of antiRSVF Fab B21m
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fab heavy chain Fd fragment, Fab light chain, ...
著者Luo, J, Tsui, P, Lewandowski, F, Spurlino, J, Vecchio, F.D.
登録日2011-02-17
公開日2011-08-10
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.699 Å)
主引用文献Crystal structure anti-RSV Fab B21m
To be Published
7C8U
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BU of 7c8u by Molmil
The crystal structure of COVID-19 main protease in complex with GC376
分子名称: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase
著者Luan, X, Shang, W, Wang, Y, Yin, W, Jiang, Y, Feng, S, Wang, Y, Liu, M, Zhou, R, Zhang, Z, Wang, F, Cheng, W, Gao, M, Wang, H, Wu, W, Tian, R, Tian, Z, Jin, Y, Jiang, H.W, Zhang, L, Xu, H.E, Zhang, S.
登録日2020-06-03
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The crystal structure of COVID-19 main protease in complex with GC376
To Be Published
3SAY
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BU of 3say by Molmil
Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142
分子名称: (3Z)-N,N-diethyl-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, (4S)-2-METHYL-2,4-PENTANEDIOL, FORMIC ACID, ...
著者Mazanetz, M.P, Cheng, R.K.Y, Rowan, F, Laughton, C.A, Barker, J.J, Fischer, P.M.
登録日2011-06-03
公開日2012-06-13
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.231 Å)
主引用文献Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142
To be Published
8GI5
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BU of 8gi5 by Molmil
Cryo-EM of self-assembling pyrene peptide with Ca2+
分子名称: Pyrene peptide
著者Rich-New, S.T, Guo, J, Xu, B, Wang, F.
登録日2023-03-13
公開日2023-06-14
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Hierarchical Assembly of Intrinsically Disordered Short Peptides.
Chem, 9, 2023
6K6L
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BU of 6k6l by Molmil
YGL082W-catalytic domain
分子名称: pseudo deubiquitinase
著者Lu, L.N, Wang, F.
登録日2019-06-03
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop
Sci China Chem, 2019
6HQE
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BU of 6hqe by Molmil
Cryo-EM of self-assembly peptide filament LRV_M3delta1
分子名称: peptide LRV_M3delta1
著者Osinski, T, Wang, F, Hughes, S.A, Kreutzberger, M.A.B, Conticello, V.P, Egelman, E.H.
登録日2018-09-24
公開日2019-06-26
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs.
Proc.Natl.Acad.Sci.USA, 116, 2019
4MR9
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BU of 4mr9 by Molmil
Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist SCH50911
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ...
著者Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R.
登録日2013-09-17
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
4MS4
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BU of 4ms4 by Molmil
Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist baclofen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ...
著者Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R.
登録日2013-09-18
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
8GYF
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BU of 8gyf by Molmil
Crystal structure of a bright green fluorescent protein (StayGold) with single mutation (K192Y) in jellyfish Cytaeis uchidae from Biortus
分子名称: 1,2-ETHANEDIOL, staygold(K192Y)
著者Wu, J, Wang, F, Gui, W, Cheng, W, Yang, Y.
登録日2022-09-22
公開日2023-10-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a bright green fluorescent protein (StayGold) with single mutation (K192Y) in jellyfish Cytaeis uchidae from Biortus
To Be Published
4MR7
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Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist CGP54626
分子名称: (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ...
著者Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R.
登録日2013-09-17
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
4MS1
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Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist CGP46381
分子名称: (S)-(3-aminopropyl)(cyclohexylmethyl)phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R.
登録日2013-09-18
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013

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件を2024-08-28に公開中

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